Modern Medical Techniques Reveal Malignant Cancer in 77-Million Year-Old Dinosaur Bone

Scientists have discovered and diagnosed the first instance of malignant cancer in a dinosaur, and they did so by using modern medical techniques. They published their results earlier this week in The Lancet Oncology.
In 1989, a badly-deformed lower leg bone of a Centrosaurus apertus was found in Dinosaur Provincial Park in Alberta, Canada. One end of the fossilized fibula was enlarged and warped, leading scientists to originally presume a healed fracture.
Centrosaurus apertus was a plant-eating, single-horned dinosaur about 20 feet long. The particular animal that the fossil comes from lived 76 to 77 million years ago and likely died in a flood that killed its entire herd.
After the bone was excavated, it sat in a museum until 2017, when a team led by David Evans, a paleontologist at the Royal Ontario Museum, and Mark Crowther, a professor of pathology at McMaster University, looked at it with fresh eyes.
"We basically went on a hunt for dinosaur cancer," Evans told NPR.
On a mission to find signs of cancer, the scientists searched through hundreds of injured or partially healed fossils before they found the malformed leg bone. The team invited multidisciplinary specialists and medical professionals from many fields, including pathology, radiology, orthopedic surgery and paleopathology, to help diagnose the suspected tumor, the news report said.
"The approach we took in this case was very similar to how we approach a patient that comes in with a new tumor, and we don't know what kind of tumor it is," said Seper Ekhtiari, an orthopedic surgery resident on the team, reported NPR.
The team performed high-resolution CT scans and examined thin sections of bone cells under a microscope, according to a Royal Ontario Museum (ROM) press release. This allowed them to visualize the progression of cancer through the bone, discounting the initial hypothesis of a fracture and leading to the diagnosis of osteosarcoma, Evans told Reuters.
Osteosarcoma generally occurs in rapidly growing bones, and is found in children and young adults, said Mark Crowther, the study's co-author and a professor of medicine, pathology and molecular medicine, Reuters reported. The tumor destroys the bone and can spread to other tissues. Dinosaurs presumably would also be at risk because they grew at enormous rates, he added.
"One of the ways they got to such massive sizes is that they grew extremely rapidly from the time when they were born," Ekhtiari told NPR. "So finding this in a dinosaur is not surprising." He also noted that bone cancer "is probably more common than we think, or more common than we have found so far."
The findings suggest that dinosaurs likely suffered from other diseases that affect bones, like tuberculosis and osteomyelitis, Crowther said, NPR reported.
To confirm the diagnosis, the scientists compared the fossil to a healthy centrosaurus fibula as well as to a human fibula confirmed with osteosarcoma, the ROM release explained.
"It is both fascinating and inspiring to see a similar multidisciplinary effort that we use in diagnosing and treating osteosarcoma in our patients leading to the first diagnosis of osteosarcoma in a dinosaur," Ekhtiari said in the ROM release. "This discovery reminds us of the common biological links throughout the animal kingdom and reinforces the theory that osteosarcoma tends to affect bones when and where they are growing most rapidly."
Evans, an expert on centrosaurus, told NPR, "We often think of dinosaurs as sort of mythical, powerful creatures, and I think this discovery really underscores that they can be afflicted by diseases that we see around us today, even horrible fatal cancers. I think in an odd way it brings them even more back to life."
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By Daisy Simmons
In a wildfire, hurricane, or other disaster, people with pets should heed the Humane Society's advice: If it isn't safe for you, it isn't safe for your animals either.
1. Stay Informed
<p>A first order of business in pet evacuation planning is to understand and be ready for the possible threats in your area. Visit <a href="https://www.ready.gov/be-informed" target="_blank">Ready.gov</a> to learn more about preparing for potential disasters such as floods, hurricanes, and wildfires. Then pay attention to related updates by tuning <a href="http://www.weather.gov/nwr/" target="_blank">NOAA Weather Radio</a> to your local emergency station or using the <a href="https://www.fema.gov/mobile-app" target="_blank">FEMA app</a> to get National Weather Service alerts.</p>2. Ensure Your Pet is Easily Identifiable
<p><span>Household pets, including indoor cats, should wear collars with ID tags that have your mobile phone number. </span><a href="https://www.avma.org/microchipping-animals-faq" target="_blank" rel="noopener noreferrer">Microchipping</a><span> your pets will also improve your chances of reunion should you become separated. Be sure to add an emergency contact for friends or relatives outside your immediate area.</span></p><p>Additionally, use <a href="https://secure.aspca.org/take-action/order-your-pet-safety-pack" target="_blank" rel="noopener noreferrer">'animals inside' door/window stickers</a> to show rescue workers how many pets live there. (If you evacuate with your pets, quickly write "Evacuated" on the sticker so first responders don't waste time searching for them.)</p>3. Make a Pet Evacuation Plan
<p> "No family disaster plan is complete without including your pets and all of your animals," says veterinarian Heather Case in <a href="https://www.youtube.com/watch?v=Q9NRJkFKAm4" target="_blank">a video</a> produced by the American Veterinary Medical Association.</p><p>It's important to determine where to take your pet in the event of an emergency.</p><p>Red Cross shelters and many other emergency shelters allow only service animals. Ask your vet, local animal shelters, and emergency management officials for information on local and regional animal sheltering options.</p><p>For those with access to the rare shelter that allows pets, CDC offers <a href="https://www.cdc.gov/healthypets/emergencies/pets-in-evacuation-centers.html" target="_blank">tips on what to expect</a> there, including potential health risks and hygiene best practices.</p><p>Beyond that, talk with family or friends outside the evacuation area about potentially hosting you and/or your pet if you're comfortable doing so. Search for pet-friendly hotel or boarding options along key evacuation routes.</p><p>If you have exotic pets or a mix of large and small animals, you may need to identify multiple locations to shelter them.</p><p>For other household pets like hamsters, snakes, and fish, the SPCA recommends that if they normally live in a cage, they should be transported in that cage. If the enclosure is too big to transport, however, transfer them to a smaller container temporarily. (More on that <a href="https://www.spcai.org/take-action/emergency-preparedness/evacuation-how-to-be-pet-prepared" target="_blank" rel="noopener noreferrer">here</a>.)</p><p>For any pet, a key step is to establish who in your household will be the point person for gathering up pets and bringing their supplies. Keep in mind that you may not be home when disaster strikes, so come up with a Plan B. For example, you might form a buddy system with neighbors with pets, or coordinate with a trusted pet sitter.</p>4. Prepare a Pet Evacuation Kit
<p>Like the emergency preparedness kit you'd prepare for humans, assemble basic survival items for your pets in a sturdy, easy-to-grab container. Items should include:</p><ul><li>Water, food, and medicine to last a week or two;</li><li>Water, food bowls, and a can opener if packing wet food;</li><li>Litter supplies for cats (a shoebox lined with a plastic bag and litter may work);</li><li>Leashes, harnesses, or vehicle restraints if applicable;</li><li>A <a href="https://www.avma.org/resources/pet-owners/emergencycare/pet-first-aid-supplies-checklist" target="_blank">pet first aid kit</a>;</li><li>A sturdy carrier or crate for each cat or dog. In addition to easing transport, these may serve as your pet's most familiar or safe space in an unfamiliar environment;</li><li>A favorite toy and/or blanket;</li><li>If your pet is prone to anxiety or stress, the American Kennel Club suggests adding <a href="https://www.akc.org/expert-advice/home-living/create-emergency-evacuation-plan-dog/" target="_blank" rel="noopener noreferrer">stress-relieving items</a> like an anxiety vest or calming sprays.</li></ul><p>In the not-unlikely event that you and your pet have to shelter in different places, your kit should also include:</p><ul><li>Detailed information including contact information for you, your vet, and other emergency contacts;</li><li>A list with phone numbers and addresses of potential destinations, including pet-friendly hotels and emergency boarding facilities near your planned evacuation routes, plus friends or relatives in other areas who might be willing to host you or your pet;</li><li>Medical information including vaccine records and a current rabies vaccination tag;</li><li>Feeding notes including portions and sizes in case you need to leave your pet in someone else's care;</li><li>A photo of you and your pet for identification purposes.</li></ul>5. Be Ready to Evacuate at Any Time
<p>It's always wise to be prepared, but stay especially vigilant in high-risk periods during fire or hurricane season. Practice evacuating at different times of day. Make sure your grab-and-go kit is up to date and in a convenient location, and keep leashes and carriers by the exit door. You might even stow a thick pillowcase under your bed for middle-of-the-night, dash-out emergencies when you don't have time to coax an anxious pet into a carrier. If forecasters warn of potential wildfire, a hurricane, or other dangerous conditions, bring outdoor pets inside so you can keep a close eye on them.</p><p>As with any emergency, the key is to be prepared. As the American Kennel Club points out, "If you panic, it will agitate your dog. Therefore, <a href="https://www.akc.org/expert-advice/home-living/create-emergency-evacuation-plan-dog/" target="_blank" rel="noopener noreferrer">pet disaster preparedness</a> will not only reduce your anxiety but will help reduce your pet's anxiety too."</p>Evacuating Horses and Other Farm Animals
<p>The same basic principles apply for evacuating horses and most other livestock. Provide each with some form of identification. Ensure that adequate food, water, and medicine are available. And develop a clear plan on where to go and how to get there.</p><p>Sheltering and transporting farm animals requires careful coordination, from identifying potential shelter space at fairgrounds, racetracks, or pastures, to ensuring enough space is available in vehicles and trailers – not to mention handlers and drivers on hand to support the effort.</p><p>For most farm animals, the Red Cross advises that you consider precautionary evacuation when a threat seems imminent but evacuation orders haven't yet been announced. The American Veterinary Medical Association has <a href="https://www.avma.org/resources/pet-owners/emergencycare/large-animals-and-livestock-disasters" target="_blank">more information</a>.</p>Bottom Line: If You Need to Evacuate, So Do Your Pets
<p>As the Humane Society warns, pets left behind in a disaster can easily be injured, lost, or killed. Plan ahead to make sure you can safely evacuate your entire household – furry members included.</p>- 5 Ways to Be an Eco-Friendly Pet Owner - EcoWatch ›
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