4 Tactics Used by Monsanto to Undermine Potential Link Between Glyphosate and Cancer
By Genna Reed
Emails unsealed in a California lawsuit last week reveal that agribusiness giant Monsanto engaged in activities aimed at undermining efforts to evaluate a potential link between glyphosate—the active ingredient of the company's popular herbicide Roundup—and cancer. The documents reveal the company's plans to seed the scientific literature with a ghostwritten study and its efforts to delay and prevent U.S. government assessments of the product's safety.
Many corporate actors, including the sugar industry, the oil and gas industries and the tobacco industry, have used tactics such as denying scientific evidence, attacking individual scientists, interfering in government decision-making processes and manufacturing counterfeit science through ghostwriting to try to convince policymakers and the public of their products' safety in the face of independent scientific evidence to the contrary. This case underscores the urgent need for greater transparency and tighter protections to prevent these kinds of corporate disinformation tactics that could put the public at risk.
Unsealed Court Documents Suggest Monsanto Ghostwrote Research to Diminish Roundup Cancer Risk https://t.co/BD8kjMQzGI @bpncamp @PAN_UK— EcoWatch (@EcoWatch)1489705806.0
High Stakes in Glyphosate-Cancer Link
The case centers on the scientific question of whether glyphosate causes a type of cancer known as non-Hodgkin lymphoma. In the California lawsuit in which the key company documents were unsealed, plaintiffs with non-Hodgkin lymphoma claim that their disease is linked to glyphosate exposure.
The science is still unclear on this question. The EPA's issue paper on this topic said that glyphosate is "not likely carcinogenic," but some of its Scientific Advisory Panel (SAP) members point to critical data gaps and even suggest that there is "limited but suggestive evidence of a positive association" between glyphosate and non-Hodgkin lymphoma. The European Food Safety Authority (EFSA) and the European Chemical Agency have both concluded that scientific evidence does not support classifying glyphosate as a carcinogen. More than 94 scientists from institutions across the world have called for changes to EFSA's scientific evaluation process.
It's complex. What is clear, however, is that independent science bodies should be conducting their assessments on glyphosate without interference from outside players with a stake in the final determination.
The stakes for public health—and for Monsanto's bottom line—are enormous. Glyphosate is one of the most widely used herbicides in the U.S. Sold by Monsanto under the trade name Roundup, it is the company's flagship product. U.S. farmers spray nearly 300 million pounds of it on corn, soybeans and a variety of other crops every year to kill weeds. It is also commonly used in the U.S. for residential lawn care. As a result of its widespread use, traces of Roundup have been found in streams and other waterways and in our food and farmers and farmworkers are at risk for potentially heavy exposure to the chemical. (More on the ramifications of its agricultural use and the related acceleration of herbicide-resistant weeds here).
Setting the Scene for Science Manipulation
In 2009, the U.S. Environmental Protection Agency (EPA) began a compulsory risk assessment of glyphosate as part of its pesticide reregistration process. The agency's process risked the possibility that the chemical could be listed as a possible carcinogen, as the agency is required to review new evidence since its last review in the mid-1990s and determine whether it will cause unreasonable adverse effects on the environment and human health. From Monsanto's standpoint, such a classification change posed a clear threat for its lucrative product, possibly resulting in changes to labels and public perception of the product's safety that could tarnish the brand's image.
Compounding the companies' woes, in March 2015, the United Nations-sponsored International Agency for Research on Cancer (IARC) released an assessment concluding that glyphosate was a probable human carcinogen after evaluating the available scientific research on glyphosate's link to non-Hodgkin lymphoma and myeloma. IARC recommended that glyphosate be classified as a 2A carcinogen, along with pesticides like DDT and malathion. IARC's was a science-based determination, not regulatory in nature. But the IARC assessment, the pending EPA review and a slated evaluation by yet another U.S. agency—the Agency for Toxic Substances and Disease Registry (ATSDR) at the Centers for Disease Control (CDC)—appears to have spurred Monsanto to use at least four separate tactics to inappropriately influence public perception and the assessment process.
Tactic 1: Suppress the Science
In one disturbing revelation, the emails suggest that Monsanto representatives had frequent communications with a U.S. government official: Jess Rowland, former associate director of the Health Effects Division at the EPA's Office of Pesticide Programs and chair of the agency's Cancer Assessment Review Committee. Internal Monsanto emails indicate that Rowland tipped the company off to the IARC assessment before its release. The emails also quote Rowland as saying he would work to quash the ATSDR study on glyphosate, reportedly telling Monsanto officials: "If I can kill this I should get a medal." The emails suggest that Monsanto was working with staff inside a U.S. government agency, outside of the established areas of public input to decision-making processes, in a completely inappropriate manner.
Tactic 2: Attack the Messenger
Immediately following the IARC assessment, Monsanto not only disputed the findings but attacked the IARC's credibility, trying to discredit the internationally renowned agency by claiming it had fallen prey to "agenda-driven bias." The IARC's working group members were shocked by Monsanto's allegations questioning their credibility. IARC relies on data that are in the public domain and follows criteria to evaluate the relevance and independence of each study it cites. As one IARC member, epidemiologist Francesco Forastiere, explained: "… none of us had a political agenda. We simply acted as scientists, evaluating the body of evidence, according to the criteria." Despite Monsanto's attacks, the IARC continues to stand by the conclusions of its 2015 assessment.
Tactic 3: Manufacture Counterfeit Science
In perhaps the most troubling revelation, emails show that in February 2015, Monsanto discussed manufacturing counterfeit science—ghostwriting a study for the scientific literature that would downplay the human health impacts of glyphosate and misrepresenting its independence. William Heydens, a Monsanto executive, suggested that the company could keep costs down by writing an article on the toxicity of glyphosate and having paid academics "edit & sign their names so to speak" and recommended that the journal Critical Reviews in Toxicology be contacted since the company "had done such a publication in the past" at that journal.
The 2000 paper Heydens referenced, the lead author of which is a faculty member at New York Medical College (NYMC), cites Monsanto studies, thanks Monsanto for "scientific support," but fails to disclose Monsanto funding or other direct involvement in its publication. That paper concluded that, "Roundup herbicide does not pose a health risk to humans." After a quick investigation to assess the integrity of this study, NYMC announced that there was "no evidence" that the faculty member had broken with the school's policy not to author ghostwritten studies.
Tactic 4: Undermine Independent Scientific Assessment
The emails and other court documents also document the ways in which Monsanto worked to prevent EPA's use of a Scientific Advisory Panel (SAP) to review the agency's issue paper on glyphosate's cancer risk and to delay and help shape the SAP findings through suggested changes to the composition of the panel. Within the unsealed emails, Monsanto mentioned that it opposed the EPA's plan to create a SAP to review glyphosate because "the scope is more likely than not to be more comprehensive than just IARC … SAPs add significant delay, create legal vulnerabilities and are a flawed process that is probable to result in a panel and determinations that are scientifically questionable and will only result in greater uncertainty." This is a bogus claim. Scientific Advisory Panels, when they are fully independent, are a critical source of science advice.
EPA's SAP meetings on glyphosate, scheduled to begin in October 2016, were postponed just a few days before they were slated to start. This occurred after intense lobbying from CropLife America, an agrichemical trade organization representing Monsanto and other pesticide makers, which questioned the motives of the SAP looking into the health impacts of glyphosate. CropLife submitted several comments to the EPA, including one that attacked the integrity of a nominated SAP scientist. The agency subsequently announced the scientist's removal from the panel in November 2016, one month before the rescheduled meetings took place.
Simultaneously, Monsanto created its own "expert panel" in July 2015 composed of 16 individuals, some scientists and some lobbyists, only four of whom have never been employed by or consulted with Monsanto. Who needs independent assessments when you have ready, willing and substantially funded agribusiness scientists who call themselves "independent"?
Defending the Scientific Process
The revelations from the unsealed Monsanto emails underscore the vital need for independent science and transparency to ensure credibility, foster public trust in our system of science-based policymaking and prevent entities like Monsanto from undermining objective scientific assessments. Clearly, better controls and oversight are needed to safeguard the scientific process from tactics like ghostwriting and more transparency and accountability are needed to ensure that scientific bodies are able to adequately assess the risks and benefits of any given product. Given what is now known about Monsanto's actions, the need for independently conducted research and impartial science-based assessments about glyphosate's safety is more important than ever.
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Fish exposed to endocrine-disrupting compounds pass on health problems to future generations, including deformities, reduced survival, and reproductive problems, according to a new study.
Low Levels Lead to Generational Impacts<p>Researchers exposed inland silverside fish to bifenthrin, levonorgestrel, ethinylestradiol, and trenbolone to levels currently found in waterways.</p><p>"Our concentrations were actually on the low end" of what is found in the wild, DeCourten said, adding that it was low amounts of chemicals in parts per trillion.</p><p>Bifenthrin is a pesticide; levonorgestrel and ethinylestradiol are synthetic hormones used in birth controls; and trenbolone is a synthetic steroid often given to cattle to bulk them up.</p><p>Such endocrine-disruptors have already been linked to a variety of health problems in directly exposed fish including altered growth, reduced survival, lowered egg production, skewed sex ratios, and negative impacts to immune systems. But what remains less clear is how the exposure may impact future generations.</p><p>For their study, DeCourten and colleagues started the exposure when the fish were embryos and continued it for 21 days.</p><p>They then tracked effects on the exposed fish, and the next two generations.</p>
Inherited Problems<p>DeCourten said the altered DNA methylation is one of the plausible ways that future generations would experience health impacts from previous generations' exposure. Hormone-disrupting compounds have been shown to impact DNA methylation, which is an important marker of how an organism will develop.</p><p>"Methyl groups are added to specific sites on the genome, [the exposure] is not changing the genome itself, but rather how the genome is expressed," she said. "And that can be inherited throughout generations."</p><p>In addition, Brander said there are essentially different "tags" that exist on DNA molecules, which tell genes how to turn on and off. She said the exposure to different compounds may be "influencing which methyl tags get taken on or off as you proceed through generations."</p><p>The researchers said the study should prompt future toxics testing to consider impacts on future generations.</p><p>"The results … throw a wrench in the current approach to regulating chemicals, where it's often short-term testing looking at simple things like growth, survival, and maybe gene expression," Brander said.</p><p>"These findings are telling us we really at least need to consider" the next two generations, she added.</p>
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By Laura Beil
Consumers have long turned to vitamins and herbs to try to protect themselves from disease. This pandemic is no different — especially with headlines that scream "This supplement could save you from coronavirus."
Vitamin D<p><strong>What it is: </strong>Called "the sunshine vitamin" because the body makes it naturally in the presence of ultraviolet light, <a href="https://www.sciencenews.org/article/vitamin-d-supplements-lose-luster" target="_blank">Vitamin D is one of the most heavily studied</a> supplements (<em>SN: 1/27/19</em>). <a href="https://health.gov/our-work/food-nutrition/2015-2020-dietary-guidelines/guidelines/appendix-12/" target="_blank">Certain foods</a>, including fish and fortified milk products, are also high in the vitamin.</p><p><strong>Why it might help: </strong>Vitamin D is a hormone building block that helps strengthen the immune system.</p><p><strong>How it works for other infections:</strong> In 2017, the <em>British Medical Journal</em> published a meta-analysis that suggested a daily vitamin D supplement <a href="https://www.bmj.com/content/356/bmj.i6583" target="_blank">might help prevent respiratory infections</a>, particularly in people who are deficient in the vitamin.</p><p>But one key word here is <em>deficient. </em>That risk is highest during dark winters at high latitudes and among people with more color in their skin (melanin, a pigment that's higher in darker skin, inhibits the production of vitamin D).</p><p>"If you have enough vitamin D in your body, the evidence doesn't stack up to say that giving you more will make a real difference," says Susan Lanham-New, head of the Nutritional Sciences Department at the University of Surrey in England.</p><p>And taking too much can create new health problems, stressing certain internal organs and leading to a dangerously high calcium buildup in the blood. The recommended daily allowance for adults is 600 to 800 International Units per day, and the upper limit is considered to be 4,000 IUs per day.</p><p><strong>What we know about Vitamin D and COVID-19:</strong> Few studies have looked directly at whether vitamin D makes a difference in COVID.</p>
Zinc<p><strong>What it is: </strong>Zinc, a mineral found in cells all over the body, is found naturally in certain meats, beans and oysters.</p><p><strong>Why it might help: </strong>It plays several supportive roles in the immune system, which is why zinc lozenges are always hot sellers in cold and flu season. Zinc also helps with cell division and growth.</p><p><strong>How it works for other infections: </strong><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457799/" target="_blank" rel="noopener noreferrer">Studies of using zinc for colds</a> — which are frequently caused by coronaviruses — suggest that using a supplement right after symptoms start might make them go away quicker. That said, a clinical trial from researchers in Finland and the United Kingdom, published in January in <em>BMJ Open</em> <a href="https://bmjopen.bmj.com/content/10/1/e031662" target="_blank" rel="noopener noreferrer">did not find any value for zinc lozenges</a> for the treatment of colds. Some researchers have theorized that inconsistencies in data for colds may be explained by varying amounts of zinc released in different lozenges.</p><p><strong>What we know about zinc and COVID-19:</strong> The mineral is promising enough that it was added to some early studies of hydroxychloroquine, a drug tested early in the pandemic. (Studies have since shown that <a href="https://www.sciencenews.org/article/covid-19-coronavirus-hydroxychloroquine-no-evidence-treatment" target="_blank">hydroxychloroquine can't prevent or treat COVID-19</a> (<em>SN: 8/2/20</em>).)</p>
Vitamin C<p><strong>What it is: </strong>Also called L-ascorbic acid, vitamin C has a long list of roles in the body. It's found naturally in fruits and vegetables, especially citrus, peppers and tomatoes.</p><p><strong>Why it might help:</strong> It's a potent antioxidant that's important for a healthy immune system and preventing inflammation.</p><p><strong>How it works for other infections: </strong>Thomas cautions that the data on vitamin C are often contradictory. One review from Chinese researchers, published in February in the <em>Journal of Medical Virolog</em>y, looked at <a href="https://onlinelibrary.wiley.com/doi/full/10.1002/jmv.25707" target="_blank">what is already known about vitamin C</a> and other supplements that might have a role in COVID-19 treatment. Among other encouraging signs, human studies find a lower incidence of pneumonia among people taking vitamin C, "suggesting that vitamin C might prevent the susceptibility to lower respiratory tract infections under certain conditions."</p><p>But for preventing colds, a 2013 Cochrane review of 29 studies <a href="https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD000980.pub4/full" target="_blank" rel="noopener noreferrer">didn't support the idea</a> that vitamin C supplements could help in the general population. However, the authors wrote, given that vitamin C is cheap and safe, "it may be worthwhile for common cold patients to test on an individual basis whether therapeutic vitamin C is beneficial."</p><p><strong>What we know about Vitamin C and COVID-19: </strong>About a dozen studies are under way or planned to examine whether vitamin C added to coronavirus treatment helps with symptoms or survival, including Thomas' study at the Cleveland Clinic.</p><p>In a review published online in July in <em>Nutrition</em>, researchers from KU Leuven in Belgium concluded that the <a href="https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD000980.pub4/full" target="_blank" rel="noopener noreferrer">vitamin may help prevent infection</a> and tamp down the dangerous inflammatory reaction that can cause severe symptoms, based on what is known about how the nutrient works in the body.</p><p>Melissa Badowski, a pharmacist who specializes in viral infections at the University of Illinois at Chicago College of Pharmacy and colleague Sarah Michienzi published an extensive look at all supplements that might be useful in the coronavirus epidemic. There's <a href="https://www.drugsincontext.com/can-vitamins-and-or-supplements-provide-hope-against-coronavirus/" target="_blank" rel="noopener noreferrer">still not enough evidence to know whether they are helpful</a>, the pair concluded in July in <em>Drugs in Context</em>. "It's not really clear if it's going to benefit patients," Badowski says.</p><p>And while supplements are generally safe, she adds that nothing is risk free. The best way to avoid infection, she says, is still to follow the advice of epidemiologists and public health experts: "Wash your hands, wear a mask, stay six feet apart."</p>
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