Glyphosate—the controversial active ingredient in Monsanto's top-selling weedkiller Roundup and other herbicides—can cause non-alcoholic fatty liver disease in rats at very low, real-world doses, according to a peer-reviewed study published in Nature.
Activists have been relabelling bottles of Monsanto's Roundup weedkiller in garden centers and DIY shops across the UK.Global Justice Now
The groundbreaking research is the first to show a "causative link between an environmentally relevant level of Roundup consumption over the long-term and a serious disease," stated lead author Dr. Michael Antoniou of King's College London, who described the findings as "very worrying."
Non-alcoholic fatty liver disease is the accumulation of extra fat in liver cells not caused by alcohol. It's a serious and common condition that affects up to 90 million people in the U.S.
For the study, the researchers used cutting-edge molecular profiling methods to examine the livers of female rats who were fed an extremely low dose of Roundup over a two-year period. The rats were administered an ultra-low dose of only 4 nanograms per kilogram of body weight per day, which is 75,000 times below EU and 437,500 below U.S. permitted levels—basically thousands of times below the amount allowed by regulators around the world.
As King's research associate Dr. Robin Mesnage explained to the
Daily Mail, "the concentration of glyphosate that was added to the drinking water of the rats corresponds to a concentration found in tap water for human consumption."
"It is also lower than the contamination of some foodstuffs," Mesnage added.
The team found evidence that consumption of low doses of glyphosate over time can cause cell damage, serious fatty liver disease and areas of dead tissue or necrosis in the livers, as the Daily Mail reported from the study.
The researchers concluded:
"The results of the study presented here imply that chronic consumption of extremely low levels of a GBH formulation (Roundup), at admissible glyphosate-equivalent concentrations, are associated with marked alterations of the liver proteome and metabolome. These changes in molecular profile overlap substantially with biomarkers of [non-alcoholic fatty liver disease] and its progression to [non-alcoholic steatohepatitis, a serious liver disease]."
"Our results also suggest that regulators should reconsider the safety evaluation of glyphosate-based herbicides," Dr. Antoniou said.
According to the American Liver Association, non-alcoholic fatty liver disease may cause the liver to swell and cause cirrhosis over time and may even lead to liver cancer or liver failure. People who are overweight, obese, or have diabetes, high cholesterol, high triglycerides are at risk of developing the condition although rapid weight loss and poor eating habits also may lead to the disease.
"Regulators worldwide accept toxicity studies in rats as indicators of human health risks. Therefore, the results of this latest study may have serious consequences for human health," the King's researchers said.
Glyphosate is the most widely applied weedkiller worldwide, especially in the U.S. Glyphosate is used on Monsanto's line of "Roundup Ready" crops such as soy, corn, canola, alfalfa and cotton that are genetically altered to withstand direct applications of the herbicide, as the product kills only the weeds.
Gross. Monsanto's #Glyphosate Most Heavily Used Weed Killer in History https://t.co/uf83Fx5WtT @ecowatch #pesticide https://t.co/g4UbJlBp0m— Center for Bio Div (@Center for Bio Div)1454529919.0
A recent analysis revealed that since 1974, when Roundup was first commercially sold, more than 1.6 billion kilograms (or 3.5 billion pounds) of glyphosate has been used in the U.S., making up 19 percent of the 8.6 billion kilograms (or 18.9 billion pounds) of glyphosate used around the world.
Glyphosate Found in Childhood Vaccines https://t.co/Jfyzw0jv5I @GreenpeaceUK @globalactplan— EcoWatch (@EcoWatch)1473592813.0
In March 2015, the World Health Organization's International Agency for Research on Cancer (IARC)
concluded that glyphosate is a "probable human carcinogen," touching off an international row on the health and safety of the widely applied herbicide. However, other regulatory agencies such as the United Nation's Food and Agriculture Organization said the ingredient is "unlikely to pose a carcinogenic risk to humans from exposure through the diet." Monsanto and other chemical companies have maintained the safety of their glyphosate-based products.
The Crop Protection Association, which speaks for Monsanto and other chemical companies, questioned the validity of the new study in a statement to the Daily Mail.
"Glyphosate is amongst the most thoroughly tested herbicides on the market, and those studies by expert regulators have consistently concluded that glyphosate does not pose a risk to public health," the association said. "Glyphosate is a crucial tool in a farmers' armory. To put things in perspective, glyphosate is less toxic than baking soda, table salt, the caffeine in our coffee and many other products we all use or consume regularly."
Monsanto also told Farmers Weekly that the results of the study should be questioned, claiming that its researchers, including Mesnage and Gilles-Eric Seralini, published similar past studies that "have been widely rejected by the international science community due to faulty science."
However, Peter Melchett, policy director at the UK's Soil Association, told Farmers Weekly, "This research is the first evidence of a clear causative link between consumption of Roundup at levels that are found in the real world and a serious disease."
The Health and Environment Alliance, a European non-profit which addresses how the environment affects health in the European Union, has also urged for a ban on glyphosate in response to the study.
"Glyphosate is already classified by IARC as a 'probable carcinogen' ... It is also described as a 'potential endocrine disrupting chemical.' This new study adds to evidence about the likely harm to human health from Roundup and other glyphosate based herbicides. Given people's unavoidable exposures from the massive increase in the use of these weed killers over the past 30 years, surely it is time to ban it on precautionary grounds?" said Génon K. Jensen, the alliance's executive director.
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More and more Americans are retrofitting their bathrooms with high-end bidets, allowing them to enjoy cleanliness and hygiene without creating as much paper waste. Not all bidets are created equal, however, and before deciding on a particular brand, it's important to do your homework. Take a look at our comprehensive Toto bidet review, and our reviews of Tushy and Omigo, to learn more about all of their options.
Toto USA<p><a href="https://www.amazon.com/TOTO-BT500B-01-Piedmont-Vertical/dp/B00084P3GO/ref=sr_1_3?crid=ZG6AGN0U9VQL&dchild=1&keywords=toto+piedmont+bidet&qid=1613591898&sprefix=toto+piedmo%2Caps%2C188&sr=8-3" target="_blank">Toto's Piedmont bidet</a> offers an elegant, classic design, and it also comes with built-in safeguards that prevent it from ever overflowing. It is available in several color options, and will look good with any contemporary bathroom design.</p><p><strong>Why buy:</strong> This is the most affordable standalone bidet in Toto's catalog. This bidet is a good option if you are remodeling your bathroom or are building a home and want to save water and paper waste from the start. Priced starting at $533, you can find it through other retailers for around $280.</p>
Toto USA<p>The <a href="https://www.amazon.com/TOTO-BT930B-01-Vertical-Cotton/dp/B0015IVUOQ/ref=sr_1_2?dchild=1&keywords=toto%2Blloyd%2Bbidet&qid=1613592001&sr=8-2&th=1" target="_blank">Lloyd bidet</a> has a much bolder, "skirted" design, but it also shares the Piedmont's flushing rim and integral overflow features, which keep you from ever experiencing spillage.</p><p><strong>Why buy: </strong>This is a fancier product with a more striking appearance, and is mainly suited for a larger, more formal design. It retails for a slightly higher price point: The Lloyd model starts at $780 in total, but you can find it for $526 through other retailers.</p>
Toto USA<p>The company's flagship standalone bidet is known as the <a href="https://www.amazon.com/TOTO-BT784B-01-Clayton-Vertical/dp/B0018L9JUC/ref=sr_1_2?dchild=1&keywords=toto+clayton+bidet&qid=1613592108&sr=8-2" target="_blank">Clayton</a>. It includes the same overflow safeguards as the other two, and of course, each of these products is backed by Toto's longstanding commitment to excellent craftsmanship.</p><p><strong>Why buy: </strong>This is the most traditional in its visual style, and, with a number of colors to choose from, it will look great in almost any bathroom design. The Clayton starts at $734, but is available through other retailers for around $426.</p>
Toto USA<p>This electronic smart bidet seat fits onto your existing toilet bowl and offers a number of comfort features, including a heated seat, automatic air deodorizer, adjustable warm water, warm air dryer, self-cleaning wand, and a wireless remote control.</p><p><strong>Why buy:</strong> We chose the <a href="https://www.amazon.com/dp/B00UCIOX2Q/ref=redir_mobile_desktop?_encoding=UTF8&aaxitk=-XjvJQOmffOcAmiCOZvtAA&hsa_cr_id=7413316040901&pd_rd_plhdr=t&pd_rd_r=0e0e7f3d-0baf-4977-85d3-663f618a76d8&pd_rd_w=Yi3yF&pd_rd_wg=LUFHB&ref_=sbx_be_s_sparkle_lsi3d_asin_1_img" target="_blank">Toto C200</a> as the overall best bidet in <a href="https://www.ecowatch.com/best-bidet-toilet-seats-2650502928.html" target="_self">our review</a> of top brands. In addition to the features mentioned, its dual action oscillating and pulsating spray and pre-mist function provide a comfortable and sanitary clean.</p>
Toto USA<p>The <a href="https://www.amazon.com/TOTO-SW3046-01-Electronic-Contemporary/dp/B078GTKSXK/ref=sr_1_2?crid=15NGPC9YFANKH&dchild=1&keywords=toto+s500e&qid=1613960063&sprefix=toto+s500e%2Caps%2C171&sr=8-2" target="_blank">Toto Washlet S500e</a> bidet seat includes the features found in the C200, plus instantaneous water heating, front and rear wash functions, two-user preset memory, and the company's <a href="https://www.totousa.com/technologies/ewater" target="_blank">EWATER+ technology</a>. This system uses electrolyzed water to keep the wand and toilet bowl clean.</p><p><strong>Why buy:</strong> This high-end Toto electric bidet seat can help you reduce water and toilet paper use, and it can help reduce the need for chemical cleaning products with its EWATER+ technology.</p>
Toto USA<p>The <a href="https://www.amazon.com/TOTO-SW2014-01-Electronic-SoftClose/dp/B0165UFOGS/ref=sr_1_1_sspa?crid=30E9Y1LAN9ZRW&dchild=1&keywords=toto+washlet+a100+elongated+bidet+toilet+seat&qid=1613589664&sprefix=toto+washlet+a100%2Caps%2C167&sr=8-1-spons&psc=1&spLa=ZW5jcnlwdGVkUXVhbGlmaWVyPUFBR1FMUTdJR1hXNUEmZW5jcnlwdGVkSWQ9QTAyNjIwOTkxUE1EWk5CQjg2QTZPJmVuY3J5cHRlZEFkSWQ9QTA0NDc1MzExSk1UMk5CQzJYVUhVJndpZGdldE5hbWU9c3BfYXRmJmFjdGlvbj1jbGlja1JlZGlyZWN0JmRvTm90TG9nQ2xpY2s9dHJ1ZQ==" target="_blank">A100</a> is an entry-level Washlet bidet attachment, but still offers numerous comfort features. It includes a heated seat with temperature control, aerated warm water with a dual action spray, and an attached arm control panel.</p><p><strong>Why buy: </strong>One of the most affordable Toto bidet options, it still lets you adjust the water temperature and pressure settings, and features rear and front cleaning functionality for a feminine wash.</p>