Quantcast

How Summer and Diet Damage Your DNA, and What You Can Do

Health + Wellness
Bob Berg / Getty Images

By Adam Barsouk

Today, your body will accumulate quadrillions of new injuries in your DNA. The constant onslaught of many forms of damage, some of which permanently mutates your genes, could initiate cancer and prove fatal. Yet all is not doomed: The lives we lead determine how well our cells can handle this daily molecular erosion.


Certain cells are particularly at risk. Your skin, for instance, is constantly being bombarded by high-energy UV light that wreaks havoc on your DNA. This UV light should not be taken lightly—1 in 5 Americans develops skin cancer in their lifetime, more than any other cancer. So as you're hitting the beach with sugary margaritas in hand, remember that deadly skin cancer rates are at record-highs, as are cancers associated with obesity.

I am a medical student in Dr. Patricia Opresko's lab at the University of Pittsburgh, which stands at the intersection of two Nobel Prize-winning disciplines: DNA repair and telomeres. Telomeres are protective regions at the ends of our chromosomes that hold the DNA together like the plastic cap on your shoelace. Her lab's work is revealing the molecular machinery that repairs your telomeres after UV and metabolic (related to energy extraction from food) damage, and the many ways it can go awry.

Telomeres: Where Chromosomes End and Our Research Begins

In the minute you've been reading, hundreds of trillions of new lesions have occurred in your DNA. Fortunately, a special class of proteins is vigilantly detecting and repairing these errors.

Repair is particularly important in telomeres.

The telomere is no small thing, at least not figuratively: Their length is correlated with many symptoms of aging. Human studies have shown that people with shorter telomeres suffer worsened immunity and heart disease along with greater mortality. With every year, your telomeres get shorter, some cells stop replicating and these symptoms worsen. We do not yet know whether telomeres are the secret to aging. What we do know is that UV and metabolic damage, which further shorten telomeres, can trigger cancer and aging; when you break the plastic cap, you unravel the whole shoelace.

Bathing our skin in UV light causes an onslaught of damage. In fact, regular skin cells from older adults have about as many mutations as cancer cells. At best, the sun's dangerous rays can cause the skin cells to commit suicide and flake off. At worst, those cells remain and become cancerous.

One such "molecular sunburn" is called a photoproduct, which forms when the energy from UV light causes two adjacent units of your DNA to stick together, potentially interfering with its normal function. Ten thousand photoproducts occur in every skin cell every day due to sun exposure.

You (and Your Telomeres) Are What You Eat

Telomeres are especially prone to such damage. And although telomeres don't contain valuable body-building instructions like genes, when photoproducts damage our telomeres, a cell can turn on a special protein called telomerase which makes the telomeres longer. This might sound like a way to stay forever young. After all, aren't short telomeres the culprit of aging? But in extending its telomeres, the cell no longer has a limit to how many times it can replicate. This explains why more than 85 percent of all cancers exhibit extended telomeres. It seems that while longer telomeres are the key to our immortality, under the wrong circumstances, they can also be our downfall. When we fail to use UV protective sunscreen to safeguard our telomeres, we are, quite literally, flying too close to the sun.

Your metabolism, which breaks down food to extract energy, generates high-energy particles called free radicals that, like UV light, can distort the units in your DNA. This, in turn, wears away at your telomeres. Such metabolic damage accumulates over a lifetime of eating. Scientists believe this is why older, overweight adults, who have spent many years metabolizing more food than average, have a far greater risk of telomere shortening and cancer. Moreover, it seems diets rich in antioxidants, found in fruits, vegetables, nuts and legumes, which counter that metabolic damage, actually protect telomeres as well.

Lengthening Our Telomeres and Our Lives

While our telomere length once seemed pre-determined by our genes, the more medical researchers learn, the more we realize the impact of our lifestyles. Smoking, UV-light exposure, obesity, lack of exercise, stress and poor diet can all diminish our telomeres, squandering our molecular fountain of youth.

In Dr. Patricia Opresko's lab, we are investigating how telomere repair keeps up with the damage wrought by our daily lives, as well as the dire consequences when it no longer can. The hope is that by better understanding the mechanisms of cancer formation, we can design better therapies. Yet our findings are important not only for treating cancer, but also for preventing it.

My grandfather lost his battle against an aggressive form of skin cancer just weeks before my bar mitzvah. My grandmother, who valued education above all else, died of cancer days prior to my high school graduation. Their untimely loss inspired me to take up research in the very center where they received their care. Every cancer cell I study, and every hallway I walk, I am reminded of my grandparents and the countless other like them that could benefit from our research.

As King Henry VIII noted, time is the only invincible opponent. My grandparents are among the billions who succumbed to the onslaught of time. In studying telomeres, many are searching for an elusive fountain of youth that can reverse aging and overcome death. Yet the answers that we uncover are far less fanciful. It is not our telomeres that shorten our lifespans but our lives that shorten our telomeres. As many as half of medical deaths in the U.S. are preventable. Small choices as simple as using UV-A and UV-B protective sunscreen, eating smarter and exercising regularly can go a long way in empowering us to take command of our health.

We still have much to learn before we can use the secrets of our telomeres to surpass the limitations of our genetic makeup. But there are countless steps you can take today to protect your telomeres from the sun and from yourself. Research barters in knowledge, but it is action, inspired by knowledge, which can keep families like mine together for longer.

Reposted with permission from our media associate The Conversation.

EcoWatch Daily Newsletter

A new study shows that half of all Arctic warming and corresponding sea-loss during the late 20th century was caused by ozone-depleting substances. Here, icebergs discharged from Greenland's Jakobshavn Glacier. Kevin Krajick / Earth Institute / EurekAlert!

The world awakened to the hole in the ozone layer in 1985, which scientists attributed it to ozone depleting substances. Two years later, in Montreal, the world agreed to ban the halogen compounds causing the massive hole over Antarctica. Research now shows that those chemicals didn't just cut a hole in the ozone layer, they also warmed up the Arctic.

Read More
Diane Wilson holds up a bag full of nurdles she collected from one of Formosa's outfall areas on Jan. 15. Julie Dermansky / DeSmogBlog

By Julie Dermansky

On the afternoon of Jan. 15, activist Diane Wilson kicked off a San Antonio Estuary Waterkeeper meeting on the side of the road across from a Formosa plastics manufacturing plant in Point Comfort, Texas.

After Wilson and the waterkeeper successfully sued Formosa in 2017, the company agreed to no longer release even one of the tiny plastic pellets known as nurdles into the region's waterways. The group of volunteers had assembled that day to check whether the plant was still discharging these raw materials of plastics manufacturing.

Read More
Sponsored

By Simon Coghlan and Kobi Leins

A remarkable combination of artificial intelligence (AI) and biology has produced the world's first "living robots."

Read More
Malaysian Environment Minister Yeo Bee Yin (front 2nd L) and officials inspect a container containing plastic waste shipment on Jan. 20, 2020 before sending back to the countries of origin. AFP via Getty Images

The Southeast Asian country Malaysia has sent 150 shipping containers packed with plastic waste back to 13 wealthy countries, putting the world on notice that it will not be the world's garbage dump, as CNN reported. The countries receiving their trash back include the United States, the United Kingdom, France and Canada.

Read More
Trump leaves after delivering a speech at the Congress Centre during the World Economic Forum annual meeting in Davos on Jan. 21, 2020. JIM WATSON / AFP via Getty Images

U.S. President Donald Trump dismissed the concerns of environmental activists as "pessimism" in a speech to political and business leaders at the start of the World Economic Forum (WEF) in Davos on Tuesday.

Read More