10,000 Dogs Needed for a Study on Canine and Human Aging
The Dog Aging Project at the University of Washington is looking to recruit 10,000 dogs to study for the next 10 years to see if they can improve the life expectancy of man's best friend and their quality of life, as CNN reported.
The project hopes that the study will also reveal something about human health, especially if they are able to identify genetic markers for particular diseases like cancer.
The researchers will collect a trove of data and test out a new drug. The data will include vet records, DNA samples, gut microbes and information on food and walks. Five hundred study participants will test out a pill that may slow the aging process, according to the AP.
"What we learn will potentially be good for dogs and has great potential to translate to human health," said project co-director Daniel Promislow of the University of Washington School of Medicine, as the AP reported.
The potential benefits to human health is what convinced National Institute on Aging at the National Institutes of Health to give the researchers a $15 million grant to conduct the study, as Geek Wire reported.
The researchers, which include teams from the University of Washington School of Medicine and the Texas A&M University College of Veterinary Medicine & Biomedical Sciences, issued a joint statement to CNN that said, "Dogs truly are science's best friend. Though they age more rapidly than humans, they get the same diseases of aging, have a rich genetic makeup, and share our environment."
"By studying aging in dogs," they said, "we can more quickly expand our knowledge of aging not just in dogs but also in humans." They added that the scientists are hopeful that their discoveries could lead to better "prediction, diagnosis, prognosis, treatment, and prevention of disease," as CNN reported.
Dogs make excellent study subjects because they are intertwined with humans.
"Unlike laboratory animals, they also share our environment," said Matt Kaeberlein, a professor of pathology at the UW School of Medicine to GeekWire. "So we absolutely believe that, in that respect, pet dogs are going to be superior to laboratory models for understanding the aging process in humans, because we're able to capture that environmental diversity."
To participate, dog owners need to complete a form on the Dog Aging Project website. Owners will have to share health and lifestyle information about their dogs. They will also be asked to share their dogs' veterinary records. Dogs will continue to live at home with their owners. All ages, sizes, purebreds and mutts are invited to participate in the study, as the AP reported.
To contribute to the study, owners will complete periodic online surveys and take their dogs to the vet annually, with the possibility of extra visits for certain tests. A bioethicist and a panel of animal welfare advisers will monitor their welfare, as the AP reported.
"All owners who complete the nomination process will become Dog Aging Project citizen scientists, and their members will become members of the Dog Aging Project 'pack,'" said Promislow in a news release, as GeekWire reported.
Since large dogs tend to have shorter lifespans than small dogs, they will be prime candidates for the pill designed to slow the aging process. The dogs chosen to experiment with rapamycin, a drug that has extended the lifespan of mice, must weigh at least 40 pounds. Kaeberlein said a small study found no dangerous side effects in dogs taking the pill, according to the AP.
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By D. André Green II
One of nature's epic events is underway: Monarch butterflies' fall migration. Departing from all across the United States and Canada, the butterflies travel up to 2,500 miles to cluster at the same locations in Mexico or along the Pacific Coast where their great-grandparents spent the previous winter.
Millions of People Care About Monarchs<p>I will never forget the sights and sounds the first time I visited monarchs' overwintering sites in Mexico. Our guide pointed in the distance to what looked like hanging branches covered with dead leaves. But then I saw the leaves flash orange every so often, revealing what were actually thousands of tightly packed butterflies. The monarchs made their most striking sounds in the Sun, when they burst from the trees in massive fluttering plumes or landed on the ground in the tussle of mating.</p><p>Decades of educational outreach by teachers, researchers and hobbyists has cultivated a generation of monarch admirers who want to help preserve this phenomenon. This global network has helped restore not only monarchs' summer breeding habitat by planting milkweed, but also general pollinator habitat by planting nectaring flowers across North America.</p><p>Scientists have calculated that restoring the monarch population to a stable level of about 120 million butterflies will require <a href="https://doi.org/10.1111/icad.12198" target="_blank">planting 1.6 billion new milkweed stems</a>. And they need them fast. This is too large a target to achieve through grassroots efforts alone. A <a href="https://www.fws.gov/savethemonarch/CCAA.html" target="_blank" rel="noopener noreferrer">new plan</a>, announced in the spring of 2020, is designed to help fill the gap.</p>
Pros and Cons of Regulation<p>The top-down strategy for saving monarchs gained energy in 2014, when the U.S. Fish and Wildlife Service <a href="https://www.fws.gov/southeast/pdf/petition/monarch.pdf" target="_blank">proposed</a> listing them as threatened under the Endangered Species Act. A decision is expected in December 2020.</p><p>Listing a species as endangered or threatened <a href="https://www.fws.gov/endangered/esa-library/pdf/listing.pdf" target="_blank">triggers restrictions</a> on "taking" (hunting, collecting or killing), transporting or selling it, and on activities that negatively affect its habitat. Listing monarchs would impose restrictions on landowners in areas where monarchs are found, over vast swaths of land in the U.S.</p><p>In my opinion, this is not a reason to avoid a listing. However, a "threatened" listing might inadvertently threaten one of the best conservation tools that we have: public education.</p><p>It would severely restrict common practices, such as rearing monarchs in classrooms and back yards, as well as scientific research. Anyone who wants to take monarchs and milkweed for these purposes would have to apply for special permits. But these efforts have had a multigenerational educational impact, and they should be protected. Few public campaigns have been more successful at raising awareness of conservation issues.</p>
<span style="display:block;position:relative;padding-top:56.25%;" class="rm-shortcode" data-rm-shortcode-id="91165203d4ec0efc30e4632a00fdf57d"><iframe lazy-loadable="true" src="https://www.youtube.com/embed/KilPRvjbMrA?rel=0" width="100%" height="auto" frameborder="0" scrolling="no" style="position:absolute;top:0;left:0;width:100%;height:100%;"></iframe></span>
The Rescue Attempt<p>To preempt the need for this kind of regulation, the U.S. Fish and Wildlife Service approved a <a href="https://www.fws.gov/savethemonarch/pdfs/Monarch%20CCAA-CCA%20Public%20Comment%20Documents/Monarch-Nationwide_CCAA-CCA_Draft.pdf" target="_blank">Nationwide Candidate Conservation Agreement for Monarch Butterflies</a>. Under this plan, "rights-of-way" landowners – energy and transportation companies and private owners – commit to restoring and creating millions of acres of pollinator habitat that have been decimated by land development and herbicide use in the past half-century.</p><p>The agreement was spearheaded by the <a href="http://rightofway.erc.uic.edu/" target="_blank">Rights-of-Way Habitat Working Group</a>, a collaboration between the University of Illinois Chicago's <a href="https://erc.uic.edu/" target="_blank" rel="noopener noreferrer">Energy Resources Center</a>, the Fish and Wildlife Service and over 40 organizations from the energy and transportation sectors. These sectors control "rights-of-way" corridors such as lands near power lines, oil pipelines, railroad tracks and interstates, all valuable to monarch habitat restoration.</p><p>Under the plan, partners voluntarily agree to commit a percentage of their land to host protected monarch habitat. In exchange, general operations on their land that might directly harm monarchs or destroy milkweed will not be subject to the enhanced regulation of the Endangered Species Act – protection that would last for 25 years if monarchs are listed as threatened. The agreement is expected to create up to 2.3 million acres of new protected habitat, which ideally would avoid the need for a "threatened" listing.</p>
A Model for Collaboration<p>This agreement could be one of the few specific interventions that is big enough to allow researchers to quantify its impact on the size of the monarch population. Even if the agreement produces only 20% of its 2.3 million acre goal, this would still yield nearly half a million acres of new protected habitat. This would provide a powerful test of the role of declining breeding and nectaring habitat compared to other challenges to monarchs, such as climate change or pollution.</p><p>Scientists hope that data from this agreement will be made publicly available, like projects in the <a href="https://www.fws.gov/savethemonarch/MCD.html" target="_blank">Monarch Conservation Database</a>, which has tracked smaller on-the-ground conservation efforts since 2014. With this information we can continue to develop powerful new models with better accuracy for determining how different habitat factors, such as the number of milkweed stems or nectaring flowers on a landscape scale, affect the monarch population.</p><p>North America's monarch butterfly migration is one of the most awe-inspiring feats in the natural world. If this rescue plan succeeds, it could become a model for bridging different interests to achieve a common conservation goal.</p>
The annual Ig Nobel prizes were awarded Thursday by the science humor magazine Annals of Improbable Research for scientific experiments that seem somewhat absurd, but are also thought-provoking. This was the 30th year the awards have been presented, but the first time they were not presented at Harvard University. Instead, they were delivered in a 75-minute pre-recorded ceremony.