Researchers from the Linus Pauling Institute at Oregon State University (OSU) and three other institutions have taken issue with recent claims that “the case is closed” on whether or not a multivitamin/mineral supplement should be taken by most people to help obtain needed micronutrients.

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In a correspondence to be published Tuesday in the Annals of Internal Medicine, the researchers reasoned that this type of dietary supplement helps fill nutritional gaps, improves general health, might help prevent chronic disease, will cause no harm and is easily worth the few cents a day that it costs.

To “call the case closed” is wrong and “misinforms the public and the medical community,” the researchers wrote. Their statements were a response to an editorial in the same publication last year that argued that such supplements are unnecessary and received widespread publicity.

The statement was authored by nutrition experts from OSU, the Children’s Hospital Oakland Research Institute, Tufts University and the Harvard School of Public Health.

While most nutrition experts agree that a balanced and nutritious diet is the best way to obtain needed nutrients, the researchers in this commentary point out that many Americans have a less-than-perfect diet—long on calories and short on nutrients—and the vast majority are not getting enough of several important vitamins and minerals.

“It’s naïve to ignore the fact that most people have micronutrient inadequacies, and wrong to condemn a daily supplement that could cover these nutritional gaps safely and at low cost,” said Balz Frei, professor and director of the Linus Pauling Institute, and a biochemist in the OSU College of Science.

“There’s strong evidence that a multivitamin/mineral supplement supports normal functioning of the body and helps improve overall health, and may even help lower chronic disease risk,” Frei said. “It’s irresponsible to ignore decades of nutrition research and tell the people of the United States they have no need for a supplement that could be so helpful, and costs as little as $1 a month.

“And if they have a poor diet, people should try to improve that as well,” he said. “The two are not mutually exclusive.”

Among the points the researchers made in their commentary:

• The vast majority of people in the U.S. do not meet all of the guidelines for dietary intake of vitamins and minerals.

• More than 93 percent of adults in the U.S. do not get the estimated average requirement of vitamins D and E from their diet; 61 percent not enough magnesium; and 50 percent not enough vitamin A and calcium.

• Many subpopulations have even more critical needs for micronutrients, including older adults, African Americans, obese persons and some people who are ill or injured.

• Concerns about “increased mortality” from supplements of vitamins A and E have been based on extremely high use through supplements far beyond the amount available in a multivitamin, and in the case of vitamin E largely refuted by comprehensive meta-analyses.

The value of proper nutrition, on the other hand, is wide-ranging and positive. Micronutrients maintain normal cell and tissue function, metabolism, growth and development. A supplement that helps a person “cover all the bases” can help protect daily, routine health.

Overt deficiency diseases such as scurvy or rickets are increasingly rare in the U.S. due to improved diet and fortified foods. However, certain vitamin and mineral deficiencies are still a major issue in the developing world, especially vitamin A, iron, iodine and zinc. According to the World Health Organization, more than 650,000 children under the age of five die around the world every year from deficiency in vitamin A.

And the potential for vitamins and other micronutrients to help reduce or prevent chronic disease continues to show promise. One of the longest, largest controlled studies ever done, the Physicians’ Health Study II, found a significant eight percent reduction in total cancer incidence in male physicians—people who, through their education, income and lifestyle, probably had diets much closer to optimal than the average American.

“There are many issues that have helped to mislead people when it comes to the study of micronutrients,” Frei said. “For instance, most research is done without first checking to see if a person is inadequate in a nutrient, and you won’t find much effect from a supplement if it isn’t needed.

“In similar fashion, too much research has been done with groups such as doctors and nurses who are probably not representative of the general population,” he said. “Whatever has been shown to be useful in such research probably would be even more effective in people who have poor diets or clear nutritional inadequacies.”

The researchers wrote in their conclusion that to “label multivitamin and mineral supplements useless, harmful and a waste of money is wrong.”

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