Quantcast
Environmental News for a Healthier Planet and Life

Help Support EcoWatch

Newly Discovered Compounds Hundreds of Times More Toxic Than Known Carcinogens

Health + Wellness

By David Stauth

Researchers at Oregon State University have discovered novel compounds produced by certain types of chemical reactions—such as those found in vehicle exhaust or grilling meat—that are hundreds of times more mutagenic than their parent compounds which are known carcinogens.

These compounds were not previously known to exist, and can be found in car and truck exhaust, amongst other places. Their discovery raises additional concerns about the health impacts of heavily-polluted urban air. Photo credit: Greenpeace

These compounds were not previously known to exist, and raise additional concerns about the health impacts of heavily-polluted urban air or dietary exposure. It’s not yet been determined in what level the compounds might be present, and no health standards now exist for them.

The findings were published in December in Environmental Science and Technology, a professional journal.

The compounds were identified in laboratory experiments that mimic the type of conditions which might be found from the combustion and exhaust in cars and trucks, or the grilling of meat over a flame.

“Some of the compounds that we’ve discovered are far more mutagenic than we previously understood, and may exist in the environment as a result of heavy air pollution from vehicles or some types of food preparation,” said Staci Simonich, a professor of chemistry and toxicology in the OSU College of Agricultural Sciences.

“We don’t know at this point what levels may be present, and will explore that in continued research,” Simonich said.

The parent compounds involved in this research are polycyclic aromatic hydrocarbons, or PAHs, formed naturally as the result of almost any type of combustion, from a wood stove to an automobile engine, cigarette or a coal-fired power plant. Many PAHs, such as benzopyrene, are known to be carcinogenic, believed to be more of a health concern than has been appreciated in the past, and are the subject of extensive research at OSU and elsewhere around the world.

The PAHs can become even more of a problem when they chemically interact with nitrogen to become “nitrated,” or NPAHs, scientists say. The newly-discovered compounds are NPAHs that were unknown to this point.

This study found that the direct mutagenicity of the NPAHs with one nitrogen group can increase six to 432 times more than the parent compound. NPAHs based on two nitrogen groups can be 272 to 467 times more mutagenic. Mutagens are chemicals that can cause DNA damage in cells that in turn can cause cancer.

For technical reasons based on how the mutagenic assays are conducted, the researchers said these numbers may actually understate the increase in toxicity—it could be even higher.

These discoveries are an outgrowth of research on PAHs that was done by Simonich at the Beijing Summer Olympic Games in 2008, when extensive studies of urban air quality were conducted, in part, based on concerns about impacts on athletes and visitors to the games.

Beijing, like some other cities in Asia, has significant problems with air quality, and may be 10-50 times more polluted than some major urban areas in the U.S. with air concerns, such as the Los Angeles basin.

An agency of the World Health Organization announced last fall that it now considers outdoor air pollution, especially particulate matter, to be carcinogenic, and cause other health problems as well. PAHs are one of the types of pollutants found on particulate matter in air pollution that are of special concern.

Concerns about the heavy levels of air pollution from some Asian cities are sufficient that Simonich is doing monitoring on Oregon’s Mount Bachelor, a 9,065-foot mountain in the central Oregon Cascade Range. Researchers want to determine what levels of air pollution may be found there after traveling thousands of miles across the Pacific Ocean.

This work was supported by the National Institute of Environmental Health Sciences (NIEHS) and the National Science Foundation. It’s also an outgrowth of the Superfund Research Program at OSU, funded by the NIEHS, that focuses efforts on PAH pollution. Researchers from the OSU College of Science, the University of California-Riverside, Texas A&M University and Peking University collaborated on the study.

Visit EcoWatch’s HEALTH page for more related news on this topic. 

EcoWatch Daily Newsletter

A protest against the name of the Washington Redskins in Minneapolis, Minnesota on Nov. 2, 2014. Fibonacci Blue / CC BY 2.0

The Washington Redskins will retire their controversial name and logo, the National Football League (NFL) team announced Monday.

Read More Show Less
The survival tools northern fish have used for millennia could be a disadvantage as environmental conditions warm and more fast-paced species move in. Istvan Banyai / Wikimedia Commons / CC by 3.0

By Alyssa Murdoch, Chrystal Mantyka-Pringle and Sapna Sharma

Summer has finally arrived in the northern reaches of Canada and Alaska, liberating hundreds of thousands of northern stream fish from their wintering habitats.

Read More Show Less
A mother walks her children through a fountain on a warm summer day on July 12, 2020 in Hoboken, New Jersey. Gary Hershorn / Getty Images

A heat wave that set in over the South and Southwest left much of the U.S. blanketed in record-breaking triple digit temperatures over the weekend. The widespread and intense heat wave will last for weeks, making the magnitude and duration of its heat impressive, according to The Washington Post.

Read More Show Less
If you get a call from a number you don't recognize, don't hit decline — it might be a contact tracer calling to let you know that someone you've been near has tested positive for the coronavirus. blackCAT / Getty Images

By Joni Sweet

If you get a call from a number you don't recognize, don't hit decline — it might be a contact tracer calling to let you know that someone you've been near has tested positive for the coronavirus.

Read More Show Less
Aerial view of burnt areas of the Amazon rainforest, near Porto Velho, Rondonia state, Brazil, on Aug. 24, 2019. CARLOS FABAL / AFP via Getty Images

NASA scientists say that warmer than average surface sea temperatures in the North Atlantic raise the concern for a more active hurricane season, as well as for wildfires in the Amazon thousands of miles away, according to Newsweek.

Read More Show Less
A baby receives limited treatment at a hospital in Yemen on June 27, 2020. Mohammed Hamoud / Anadolu Agency / Getty Images

By Andrea Germanos

Oxfam International warned Thursday that up to 12,000 people could die each day by the end of the year as a result of hunger linked to the coronavirus pandemic—a daily death toll surpassing the daily mortality rate from Covid-19 itself.

Read More Show Less

Trending

The 2006 oil spill was the largest incident in Philippine history and damaged 1,600 acres of mangrove forests. Shubert Ciencia / Flickr / CC BY 2.0

By Jun N. Aguirre

An oil spill on July 3 threatens a mangrove forest on the Philippine island of Guimaras, an area only just recovering from the country's largest spill in 2006.

Read More Show Less