Single Dose of 'Magic Mushrooms' Provides Long-Term Anxiety Relief for Cancer Patients, Study Suggests
Not only did the patients feel reductions in anxiety, a slew of other mental health symptoms were relieved as well, including depression, hopelessness, demoralization and death anxiety, according to CNN.
In addition to self-reported improved well-being or life satisfaction, some patients rated the treatment as being "among the most personally meaningful and spiritually significant experiences of their lives," the authors wrote, as Medscape Medical News reported.
The study, published in the Journal of Psychopharmacology, followed up on a study published in 2016 that gave cancer patients a single dose of synthetic psilocybin, the psychoactive chemical present in mushrooms, in a controlled setting where the patients were monitored the entire time, as NBC News reported.
The study was featured recently in the documentary Fantastic Fungi.
The new follow-up tracked 15 of the first 29 participants from the study nearly five years after their guided experience with synthetic psilocybin. After five years, nearly 80 percent were still experiencing significant improvements in cancer-related depression and anxiety. Furthermore, almost all of the participants chalked up their positive life changes to the psychedelic-assisted therapy, according to NBC News.
"Our findings strongly suggest that psilocybin therapy is a promising means of improving the emotional, psychological, and spiritual well-being of patients with life-threatening cancer," said Dr. Stephen Ross, associate professor of psychiatry in the Department of Psychiatry at NYU Langone Health, as CNN reported.
"This approach has the potential to produce a paradigm shift in the psychological and existential care of patients with cancer, especially those with terminal illness," Ross added, as Medscape Medical News reported.
That said, it is important to note that this was a single controlled-dose from pharmacy-made synthetic psilocybin, and a trained nurse monitored the patients while they were under the influence of the narcotic. Possessing hallucinogenic mushrooms is a felony and ingesting them is potentially hazardous.
The researchers are not sure why psilocybin produced such long-lasting relief, but they previously theorized that it has to do with the brain's neuroplasticity — the brain's ability to adapt and change with various experiences, according to CNN.
"These results may shed light on how the positive effects of a single dose of psilocybin persist for so long," said Gabby Agin-Liebes, lead investigator and lead author of the long-term follow-up study, and co-author of the 2016 parent study. "The drug seems to facilitate a deep, meaningful experience that stays with a person and can fundamentally change his or her mindset and outlook."
One of the patients, Dinah Bazer, suffered from ovarian cancer in her 60s. After a successful round of chemotherapy, her anxiety inexplicably overwhelmed her.
"I thought that when the chemo ended, I would celebrate but instead, I went into a tailspin. Even though my prognosis was really excellent, I was worried about a relapse," Bazer said to NBC News. After her experience with synthetic psilocybin, Bazer went through six-months of no anxiety at all.
"What is permanent is that I don't have anxiety about cancer. Not only about my cancer returning, but how I viewed my reoccurrence when it did happen," said Bazer, who was diagnosed last March with a type of rare gastrointestinal cancer, as NBC News reported.
While the results are promising, they are limited because of the small number of patients in the study and the follow-up.
"The conclusions that can be drawn are limited because the original trial was a crossover design," said James Rucker, who leads the Psychedelic Trials Group at the Centre for Affective Disorders at Kings College London in the UK, to CNN. "This means that in the original trial every participant eventually received psilocybin. Because of this, there is no control group in this current study. This means that we do not know whether the participants might have improved long term anyway, regardless of the treatment."
However, Ross sees a bright future for the future of psilocybin in oncology.
"This could profoundly transform the psycho-oncologic care of patients with cancer, and importantly could be used in hospice settings to help terminally ill cancer patients approach death with improved emotional and spiritual well-being," Ross said, as CNN reported.
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EcoWatch Daily Newsletter
The 2020 hurricane season is now expected to be the most active since at least the early 1980s, meteorologists at Colorado State University, a standard bearer for seasonal hurricane predictions, announced Wednesday.
Three years ago, scientists predicted it would happen. Now, new NASA satellite imagery confirms it's true: two ice caps in Canada's Nunavut province have disappeared completely, providing more visual evidence of the rapid warming happening near the poles, as CTV News in Canada reported.
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By Katell Ané
The European Commission launched a new Farm to Fork strategy in an effort to reduce the social and environmental impact of the European food system. It is the newest strategy under the European Green Deal, setting sustainability targets for farmers, consumers, and policymakers.
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By Alexander Freund
Lebanese Prime Minister Hassan Diab says he believes Tuesday's explosion in Beirut could have been caused by large quantities of ammonium nitrate stored in the port.
What Is Ammonium Nitrate?<p>Ammonium nitrate is a white crystalline salt that can be fairly cheaply produced from ammonia and nitric acid. It is soluble and often used as fertilizer, as nitrogen is needed for healthy plant development.</p><p>Ammonium nitrate in its pure form is not dangerous. It is, however, heat sensitive. At 32.2 degrees Celsius (89.96 degrees Fahrenheit), ammonium nitrate changes its atomic structure, which in turn changes its chemical properties.</p><p>When large quantities of ammonium nitrate are stored in one place, heat is generated. If the amount is sufficiently vast, it can cause the chemical to ignite. Once a temperature of 170 C is reached, ammonium nitrate starts breaking down, emitting nitrous oxide, better known as laughing gas. Any sudden ignition causes ammonium nitrate to decompose directly into water, nitrogen and oxygen, which explains the enormous explosive power of the salt.</p>
Deadly Disasters<p>As ammonium nitrate is a highly explosive chemical, many countries strictly regulate its use. Over the past 100 years, there have been several disasters involving the chemical.</p><p>In 1921, for example, a massive blast occurred at a BASF chemical plant in Ludwigshafen in the German state of Rhineland-Palatinate. About 400 metric tons of a mixture of ammonium sulfate and ammonium nitrate exploded, killing 559 people and injuring 1,977. The plant was largely destroyed in the blast, which could be heard as far away as Munich, some 300 kilometers (186 miles) distant.</p><p>In 2015, explosions caused by ammonium nitrate ripped through the <a href="https://www.dw.com/en/china-convicts-dozens-for-last-years-giant-explosions-in-tianjin/a-36324321" target="_blank">Chinese port city of Tianjin</a>. Eight hundred metric tons of the chemical were said to have been stored along with other substances in a warehouse for hazardous materials. The blasts killed 173 people and destroyed an entire city district.</p><p>Two years earlier, in 2013, an ammonium nitrate explosion occurred at the West Fertilizer Company site in Texas, killing 14 people. And in 2001, 31 people died in Toulouse, France, in an explosion caused by the chemical.</p>
Terrorist Favorite<p>In Germany, the purchase and use of ammonium nitrate is regulated by the explosives act. This is because the cheap, highly explosive and relatively easily obtainable material has in the past been used by terrorists to carry out attacks.</p><p>For example, in 1995, U.S. conspiracy theorist and gun enthusiast Timothy McVeigh used a mixture of ammonium nitrate and other substances to bomb the Alfred P. Murrah Federal Building in Oklahoma City. Norwegian far-right extremist Anders Behring Breivik also used ammonium nitrate in a car bomb attack in Oslo in 2011.</p>
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By Michelle D. Holmes
Most Americans know about the Dietary Guidelines for Americans primarily through their colorful representations: the original food pyramid, which a few years ago morphed into MyPlate. The guidelines represent the government mothering us to choose the healthiest vegetables, grains, sources of protein, and desserts, and to eat them in the healthiest portions.
As innocuous as the food pyramid and MyPlate seem, they are actually a matter of life and death.
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