
By Marlene Cimons
Last summer, scientist Maria Rodriguez traveled to the Peruvian region of Madre de Dios, once the home of lush rainforests, meandering rivers and thriving wildlife. But her destination was anything but picturesque. She'd come to study several sites ravaged by illegal gold mining that had left a legacy of destruction and mercury poisoning. One area, in fact, resembled a lunar landscape, rather than a rainforest.
"No more trees, very dry, full of sand and rocks," she said. "We couldn't believe what our eyes were seeing. How did this happen?"
It happened because small-scale artisanal gold miners had been defying the law by working there, using toxic mercury to separate gold from the soil and river sediments. They extract the sediments from the river, pile them on the riverbanks, and then add mercury. Finally, they burn the mix, isolating the gold and releasing most of the mercury into the air. The remaining mercury stays in the soil, or ends up in the water, threatening wildlife, plants — and people.
At one point, Rodriguez and her colleagues traveled 45 minutes through the fog by riverboat, spotting small boats at the river banks, dredges that remove the sediments from the river.
"Miners were working under these black plastic roofs and some of them inside the river or at the riverbanks," she recalled. "We even saw families with children. This was very frustrating because we knew they were polluting this beautiful environment, and also contaminating themselves. The mercury can affect the nervous system after exposure, especially in children."
A mining site in the Amazon.
Maria Rodriguez
Rodriguez, a University of Maryland environmental engineering doctoral candidate in the A. James Clark School of Engineering, went to Peru with faculty mentors Natasha Andrade and Alba Torrents to assess the mercury damage there. The field trip was the start of a long-term project sponsored by the school and by CINCIA, the Center for Amazonian Scientific Innovation, which is working on the ground in Peru to reforest degraded areas in Peru. Rodriguez hopes the partnership will help restore the Peruvian region which, she says, already has lost nearly 250,000 acres to artisanal gold-mining in the last two decades.
While most recent attention has focused on wildfires that have been raging in the Amazon rainforest, which soak up carbon pollution and are often described as the "lungs" of our planet, other serious threats exist in the region, illegal gold mining and its use of mercury chief among them.
In Peru, the illegal mining is performed by individuals and small companies, many of the workers poor people from Andean regions, Rodriguez said. "But their activity is controlled by criminal organizations," she said. "The artisanal activity has been performed in the Peruvian Amazon from the 1980's but has increased in recent decades due to the high price of gold in the international markets."
A former mining site in the Amazon rainforest.
Natasha Andrade
Because mercury is destroying soils and foliage in the area, the scientists' goal is to rejuvenate the forest by planting new species of vegetation that can withstand exposure to the poisonous element. Rodriguez hopes to determine the toxic threshold of mercury for the new-growth plants, species that include achiote, cocona and yucca, so that they can be planted safely and not pose a danger to people who later consume them.
Through tests and analyses, the researchers hope to figure out whether the new plants will grow in the contaminated soil, and how much soil needs to be cleared to eliminate the hazard. The findings also will help them predict whether new trees will grow there.
Latin America illegally extracts the world's highest percentage of gold, according to the Global Initiative Against Transnational Organized Crime, with Venezuela, Colombia, Ecuador, Bolivia, and Peru topping the list.
"All the Amazonian countries in South America are suffering the impacts," she said. "This is gold mining conducted by individual miners or small enterprises with limited capital investment and production. They don't use safety protection or procedures to prevent environmental pollution." A 2018 report cited more than 2,000 Amazon locations with unregulated mining, she said.
Dredge in Madre de Dios river.
Natasha Andrade
The definition of "illegal" differs by country, she added. "For example, in Peru, mining in national parks and their surrounding area is forbidden," she said. "It's also forbidden in rivers. In Brazil, artisanal mining in rivers is allowed. Some miners perform the activity in non-forbidden areas, with a permit from the government, but they use procedures that increase deforestation and contaminate soil, air and water with mercury."
The Peruvian government has tried fighting it with its military, the most recent operation in February, she said. "They expelled the miners from the mining sites in the national parks and installed military bases there," she explained. "But the maintenance of these bases is expensive. In similar operations in the past years, once the military left, the miners went back to the sites."
Moreover, ending these activities is made more difficult because gold is bought and sold by a network of middlemen who provide false receipts, allowing export companies to buy the gold, which is refined abroad, she added.
A former mining site in an indigenous territory in the Amazon.
Natasha Andrade
The World Gold Council, the global trade organization for the pure gold mining industry, won't comment on illegal mining. "However, we do work closely with our mining members on [environmental, social and governance] initiatives," said Iya Davidson, a spokeswoman for the organization. The organization recently released Responsible Gold Mining Principles, a framework for consumers, investors and the supply chain, which, among other things, urges "respect for the environment."
Miles Silman, a Wake Forest University biologist and CINCIA's associate director of science, stressed the importance of good governance. "The profit from mining can be very large, so if a society decides to do it, they should make sure it is governed in a way where the benefits of the activity are worth the environmental destruction," he said.
Rodriguez pointed out that the public likely knows little about controversial gold mining practices. "I think consumers are not aware of this problem because they are not even aware that they are consuming gold," Rodriguez said. "Gold is not only use for jewelry or gold bars, but also for electronic devices, like cellphones. I'm sure that campaigns like the ones about blood diamonds could help to reduce the extent of illegal gold mining."
While in Peru, Rodriguez visited the indigenous communities of San Jacinte and Kotsimba — home to the Shipibo and Harakbut people, respectively — where mining had left dead soil behind where nothing can grow. "The indigenous don't want the miners to work in their territory but can't do anything about it," she said. "This is a common issue in this region."
Many of the indigenous people asked about the possibility of soil treatments and other efforts that could help regenerate the forest, hoping to encourage ecotourism, she said.
"They wondered whether anyone will come to visit this ugly landscape," she said. "They want their forest back. We felt very sad knowing that the forest will take hundreds of years to recover."
Reposted with permission from our media associate Nexus Media.
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A Healthy Microbiome Builds a Strong Immune System That Could Help Defeat COVID-19
By Ana Maldonado-Contreras
Takeaways
- Your gut is home to trillions of bacteria that are vital for keeping you healthy.
- Some of these microbes help to regulate the immune system.
- New research, which has not yet been peer-reviewed, shows the presence of certain bacteria in the gut may reveal which people are more vulnerable to a more severe case of COVID-19.
You may not know it, but you have an army of microbes living inside of you that are essential for fighting off threats, including the virus that causes COVID-19.
How Do Resident Bacteria Keep You Healthy?
<p>Our immune defense is part of a complex biological response against harmful pathogens, such as viruses or bacteria. However, because our bodies are inhabited by trillions of mostly beneficial bacteria, virus and fungi, activation of our immune response is tightly regulated to distinguish between harmful and helpful microbes.</p><p>Our bacteria are spectacular companions diligently helping prime our immune system defenses to combat infections. A seminal study found that mice treated with antibiotics that eliminate bacteria in the gut exhibited an impaired immune response. These animals had low counts of virus-fighting white blood cells, weak antibody responses and poor production of a protein that is vital for <a href="https://doi.org/10.1073/pnas.1019378108" target="_blank">combating viral infection and modulating the immune response</a>.</p><p><a href="https://doi.org/10.1371/journal.pone.0184976" target="_blank" rel="noopener noreferrer">In another study</a>, mice were fed <em>Lactobacillus</em> bacteria, commonly used as probiotic in fermented food. These microbes reduced the severity of influenza infection. The <em>Lactobacillus</em>-treated mice did not lose weight and had only mild lung damage compared with untreated mice. Similarly, others have found that treatment of mice with <em>Lactobacillus</em> protects against different <a href="https://doi.org/10.1038/srep04638" target="_blank" rel="noopener noreferrer">subtypes of</a> <a href="https://doi.org/10.1038/s41598-017-17487-8" target="_blank" rel="noopener noreferrer">influenza</a> <a href="https://doi.org/10.1371/journal.ppat.1008072" target="_blank" rel="noopener noreferrer">virus</a> and human respiratory syncytial virus – the <a href="https://doi.org/10.1038/s41598-019-39602-7" target="_blank" rel="noopener noreferrer">major cause of viral bronchiolitis and pneumonia in children</a>.</p>Chronic Disease and Microbes
<p>Patients with chronic illnesses including Type 2 diabetes, obesity and cardiovascular disease exhibit a hyperactive immune system that fails to recognize a harmless stimulus and is linked to an altered gut microbiome.</p><p>In these chronic diseases, the gut microbiome lacks bacteria that activate <a href="https://doi.org/10.1126/science.1198469" target="_blank" rel="noopener noreferrer">immune cells</a> that block the response against harmless bacteria in our guts. Such alteration of the gut microbiome is also observed in <a href="https://doi.org/10.1073/pnas.1002601107" target="_blank" rel="noopener noreferrer">babies delivered by cesarean section</a>, individuals consuming a poor <a href="https://doi.org/10.1038/nature12820" target="_blank" rel="noopener noreferrer">diet</a> and the <a href="https://doi.org/10.1038/nature11053" target="_blank" rel="noopener noreferrer">elderly</a>.</p><p>In the U.S., 117 million individuals – about half the adult population – <a href="https://health.gov/our-work/food-nutrition/2015-2020-dietary-guidelines/guidelines/" target="_blank" rel="noopener noreferrer">suffer from Type 2 diabetes, obesity, cardiovascular disease or a combination of them</a>. That suggests that half of American adults carry a faulty microbiome army.</p><p>Research in my laboratory focuses on identifying gut bacteria that are critical for creating a balanced immune system, which fights life-threatening bacterial and viral infections, while tolerating the beneficial bacteria in and on us.</p><p>Given that diet affects the diversity of bacteria in the gut, <a href="https://www.umassmed.edu/nutrition/melody-trial-info/" target="_blank" rel="noopener noreferrer">my lab studies show how diet can be used</a> as a therapy for chronic diseases. Using different foods, people can shift their gut microbiome to one that boosts a healthy immune response.</p><p>A fraction of patients infected with SARS-CoV-2, the virus that causes COVID-19 disease, develop severe complications that require hospitalization in intensive care units. What do many of those patients have in common? <a href="https://www.cdc.gov/mmwr/volumes/69/wr/mm6912e2.htm" target="_blank" rel="noopener noreferrer">Old age</a> and chronic diet-related diseases like obesity, Type 2 diabetes and cardiovascular disease.</p><p><a href="http://doi.org/10.1016/j.jada.2008.12.019" target="_blank" rel="noopener noreferrer">Black and Latinx people are disproportionately affected by obesity, Type 2 diabetes and cardiovascular disease</a>, all of which are linked to poor nutrition. Thus, it is not a coincidence that <a href="https://www.cdc.gov/mmwr/volumes/69/wr/mm6933e1.htm" target="_blank" rel="noopener noreferrer">these groups have suffered more deaths from COVID-19</a> compared with whites. This is the case not only in the U.S. but also <a href="https://www.washingtonpost.com/world/europe/blacks-in-britain-are-four-times-as-likely-to-die-of-coronavirus-as-whites-data-show/2020/05/07/2dc76710-9067-11ea-9322-a29e75effc93_story.html" target="_blank" rel="noopener noreferrer">in Britain</a>.</p>Discovering Microbes That Predict COVID-19 Severity
<p>The COVID-19 pandemic has inspired me to shift my research and explore the role of the gut microbiome in the overly aggressive immune response against SARS-CoV-2 infection.</p><p>My colleagues and I have hypothesized that critically ill SARS-CoV-2 patients with conditions like obesity, Type 2 diabetes and cardiovascular disease exhibit an altered gut microbiome that aggravates <a href="https://theconversation.com/exercise-may-help-reduce-risk-of-deadly-covid-19-complication-ards-136922" target="_blank" rel="noopener noreferrer">acute respiratory distress syndrome</a>.</p><p>Acute respiratory distress syndrome, a life-threatening lung injury, in SARS-CoV-2 patients is thought to develop from a <a href="http://doi.org/10.1016/j.cytogfr.2020.05.003" target="_blank" rel="noopener noreferrer">fatal overreaction of the immune response</a> called a <a href="https://theconversation.com/blocking-the-deadly-cytokine-storm-is-a-vital-weapon-for-treating-covid-19-137690" target="_blank" rel="noopener noreferrer">cytokine storm</a> <a href="http://doi.org/10.1016/S2213-2600(20)30216-2" target="_blank" rel="noopener noreferrer">that causes an uncontrolled flood</a> <a href="http://doi.org/10.1016/S2213-2600(20)30216-2" target="_blank" rel="noopener noreferrer">of immune cells into the lungs</a>. In these patients, their own uncontrolled inflammatory immune response, rather than the virus itself, causes the <a href="http://doi.org/10.1007/s00134-020-05991-x" target="_blank" rel="noopener noreferrer">severe lung injury and multiorgan failures</a> that lead to death.</p><p>Several studies <a href="https://doi.org/10.1016/j.trsl.2020.08.004" target="_blank" rel="noopener noreferrer">described in one recent review</a> have identified an altered gut microbiome in patients with COVID-19. However, identification of specific bacteria within the microbiome that could predict COVID-19 severity is lacking.</p><p>To address this question, my colleagues and I recruited COVID-19 hospitalized patients with severe and moderate symptoms. We collected stool and saliva samples to determine whether bacteria within the gut and oral microbiome could predict COVID-19 severity. The identification of microbiome markers that can predict the clinical outcomes of COVID-19 disease is key to help prioritize patients needing urgent treatment.</p><p><a href="https://doi.org/10.1101/2021.01.05.20249061" target="_blank" rel="noopener noreferrer">We demonstrated</a>, in a paper which has not yet been peer reviewed, that the composition of the gut microbiome is the strongest predictor of COVID-19 severity compared to patient's clinical characteristics commonly used to do so. Specifically, we identified that the presence of a bacterium in the stool – called <em>Enterococcus faecalis</em>– was a robust predictor of COVID-19 severity. Not surprisingly, <em>Enterococcus faecalis</em> has been associated with <a href="https://doi.org/10.1053/j.gastro.2011.05.035" target="_blank" rel="noopener noreferrer">chronic</a> <a href="https://doi.org/10.1016/S0002-9440(10)61172-8" target="_blank" rel="noopener noreferrer">inflammation</a>.</p><p><em>Enterococcus faecalis</em> collected from feces can be grown outside of the body in clinical laboratories. Thus, an <em>E. faecalis</em> test might be a cost-effective, rapid and relatively easy way to identify patients who are likely to require more supportive care and therapeutic interventions to improve their chances of survival.</p><p>But it is not yet clear from our research what is the contribution of the altered microbiome in the immune response to SARS-CoV-2 infection. A recent study has shown that <a href="https://doi.org/10.1101/2020.12.11.416180" target="_blank" rel="noopener noreferrer">SARS-CoV-2 infection triggers an imbalance in immune cells</a> called <a href="https://doi.org/10.1111/imr.12170" target="_blank" rel="noopener noreferrer">T regulatory cells that are critical to immune balance</a>.</p><p>Bacteria from the gut microbiome are responsible for the <a href="https://doi.org/10.7554/eLife.30916.001" target="_blank" rel="noopener noreferrer">proper activation</a> <a href="https://doi.org/10.1126/science.1198469" target="_blank" rel="noopener noreferrer">of those T-regulatory</a> <a href="https://doi.org/10.1038/nri.2016.36" target="_blank" rel="noopener noreferrer">cells</a>. Thus, researchers like me need to take repeated patient stool, saliva and blood samples over a longer time frame to learn how the altered microbiome observed in COVID-19 patients can modulate COVID-19 disease severity, perhaps by altering the development of the T-regulatory cells.</p><p>As a Latina scientist investigating interactions between diet, microbiome and immunity, I must stress the importance of better policies to improve access to healthy foods, which lead to a healthier microbiome. It is also important to design culturally sensitive dietary interventions for Black and Latinx communities. While a good-quality diet might not prevent SARS-CoV-2 infection, it can treat the underlying conditions related to its severity.</p><p><em><a href="https://theconversation.com/profiles/ana-maldonado-contreras-1152969" target="_blank">Ana Maldonado-Contreras</a> is an assistant professor of Microbiology and Physiological Systems at the University of Massachusetts Medical School.</em></p><p><em>Disclosure statement: Ana Maldonado-Contreras receives funding from The Helmsley Charitable Trust and her work has been supported by the American Gastroenterological Association. She received The Charles A. King Trust Postdoctoral Research Fellowship. She is also member of the Diversity Committee of the American Gastroenterological Association.</em></p><p><em style="">Reposted with permission from <a href="https://theconversation.com/a-healthy-microbiome-builds-a-strong-immune-system-that-could-help-defeat-covid-19-145668" target="_blank" rel="noopener noreferrer" style="">The Conversation</a>. </em></p>By Jeff Masters, Ph.D.
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