
William D. Hartung
There was a time when nuclear weapons were a significant part of our national conversation. Addressing the issue of potential atomic annihilation was once described by nuclear theorist Herman Kahn as “thinking about the unthinkable,” but that didn’t keep us from thinking, talking, fantasizing, worrying about it, or putting images of possible nuclear nightmares (often transmuted to invading aliens or outer space) endlessly on screen.
Now, on a planet still overstocked with city-busting, world-ending weaponry, in which almost 67 years have passed since a nuclear weapon was last used, the only nuke that Americans regularly hear about is one that doesn’t exist: Iran’s. The nearly 20,000 nuclear weapons on missiles, planes and submarines possessed by Russia, the U.S., France, the United Kingdom, China, Israel, Pakistan, India and North Korea are barely mentioned in what passes for press coverage of the nuclear issue.
Today, nuclear destruction finds itself at the end of a long queue of anxieties about our planet and its fate. For some reason, we trust ourselves, our allies and even our former enemies with nuclear arms—evidently so deeply that we don’t seem to think the staggering arsenals filled with weaponry that could put the devastation of Hiroshima to shame are worth covering or dealing with. Even the disaster at Fukushima last year didn’t revive an interest in the weaponry that goes with the “peaceful” atom in our world.
Attending to the Bomb in a MAD World
Our views of the nuclear issue haven’t always been so shortsighted. In the 1950s, editor and essayist Norman Cousins was typical in frequently tackling nuclear weapons issues for the widely read magazine Saturday Review. In the late 1950s and beyond, the Ban the Bomb movement forced the nuclear weapons issue onto the global agenda, gaining international attention when it was revealed that Strontium-90, a byproduct of nuclear testing, was making its way into mothers’ breast milk. In those years, the nuclear issue became personal as well as political.
In the early 1960s, President John F. Kennedy responded to public pressure by signing a treaty with Russia that banned atmospheric nuclear testing (and so further Strontium-90 fallout). He also gave a dramatic speech to the United Nations in which he spoke of the nuclear arms race as a “sword of Damocles” hanging over the human race, poised to destroy us at any moment.
Popular films like Fail-Safe and Dr. Strangelove captured both the dangers and the absurdity of the superpower arms race. And when, on the night of Oct. 22, 1962, Kennedy took to the airwaves to warn the American people that a Cuban missile crisis was underway, that it was nuclear in nature, that a Soviet nuclear attack and a “full retaliatory strike on the Soviet Union” were possibilities—arguably the closest we have come to a global nuclear war—it certainly got everyone’s attention.
All things nuclear receded from public consciousness as the Vietnam War escalated and became the focus of antiwar activism and debate, but the nuclear issue came back with a vengeance in the Reagan years of the early 1980s when superpower confrontations once again were in the headlines. A growing anti-nuclear movement first focused on a near-disaster at the Three Mile Island nuclear plant in Pennsylvania (the Fukushima of its moment) and then on the superpower nuclear stand-off that went by the name of “mutually assured destruction” or, appropriately enough, the acronym MAD.
The Nuclear Freeze Campaign generated scores of anti-nuclear resolutions in cities and towns around the country, and in June 1982, a record-breaking million people gathered in New York City’s Central Park to call for nuclear disarmament. If anyone managed to miss this historic outpouring of anti-nuclear sentiment, ABC news aired a prime-time, made-for-TV movie, The Day After, that offered a remarkably graphic depiction of the missiles leaving their silos and the devastating consequences of a nuclear war. It riveted a nation.
The collapse of the Soviet Union and the end of that planetary superpower rivalry less than a decade later took nuclear weapons out of the news. After all, with the Cold War over and no other rivals to the U.S., who needed such weaponry or a MAD world either? The only problem was that the global nuclear landscape was left more or less intact, mission-less but largely untouched (with the proliferation of the weapons to other countries ongoing). Unacknowledged as it may be, in some sense MAD still exists, even if we prefer to pretend that it doesn’t.
A MAD World That No One Cares to Notice
More than 20 years later, the only nuclear issue considered worth the bother is stopping the spread of the bomb to a couple of admittedly scary and problematic regimes: Iran and North Korea. Their nuclear efforts make the news regularly and garner attention (to the point of obsession) in media and government circles. But remind me: when was the last time you read about what should be the ultimate (and obvious) goal—getting rid of nuclear weapons altogether?
This has been our reality, despite President Obama’s pledge in Prague back in 2009 to seek “the peace and security of a world without nuclear weapons,” and the passage of a modest but important New START arms reduction treaty between the U.S. and Russia in 2010. It remains our reality, despite a dawning realization in budget-anxious Washington that we may no longer be able to afford to throw money (as presently planned) at nuclear projects ranging from new ballistic-missile submarines to new facilities for building nuclear warhead components—all of which are slated to keep the secret global nuclear arms race alive and well decades into the future.
If Iran is worth talking about—and it is, given the implications of an Iranian bomb for further nuclear proliferation in the Middle East—what about the arsenals of the actual nuclear states? What about Pakistan, a destabilizing country which has at least 110 nuclear warheads and counting, and continues to view India as its primary adversary despite U.S. efforts to get it to focus on al-Qaeda and the Taliban? What about India’s roughly 100 nuclear warheads, meant to send a message not just to Pakistan but to neighboring China as well? And will China hold pat at 240 or so nuclear weapons in the face of U.S. nuclear modernization efforts and plans to surround it with missile defense systems that could, in theory if not practice, blunt China’s nuclear deterrent force?
Will Israel continue to get a free pass on its officially unacknowledged possession of up to 200 nuclear warheads and its refusal to join the Nuclear Non-Proliferation Treaty? Who are France and the United Kingdom targeting with their forces of 300 and 225 nuclear warheads, respectively? How long will it take North Korea to develop miniaturized nuclear bombs and deploy them on workable, long-range missiles? And is New START the beginning or the end of mutual U.S. and Russian arms reductions?
Many of these questions are far more important than whether Iran gets the bomb, but they get, at best, only a tiny fraction of the attention that Tehran’s nuclear program is receiving. Concern about Pakistan’s nuclear arsenal and a fear of loose nukes in a destabilizing country is certainly part of the subtext of U.S. policy towards Islamabad. Little effort has been made of late, however, to encourage Pakistan and India to engage in talks aimed at reconciling their differences and opening the way for discussions on reducing their nuclear arsenals.
The last serious effort—centered on the contentious issue of Kashmir—reached its high point in 2007 under the regime of Pakistani autocrat Pervez Musharraf, and it went awry in the wake of political changes within his country and Pakistani-backed terrorist attacks on India. If anything, the tensions now being generated by U.S. drone strikes in Pakistan’s tribal borderlands and other affronts, intended or not, to Pakistan’s sovereignty have undermined any possibility of Washington brokering a rapprochement between Pakistan and India.
In addition, starting in the Bush years, the U.S. has been selling India nuclear fuel and equipment. This has been part of a controversial agreement that violates prior U.S. commitments to forgo nuclear trade with any nation that has refused to join the Nuclear Non-Proliferation Treaty (a pact India has not signed). Although U.S. assistance is nominally directed towards India’s civilian nuclear program, it helps free up resources that India can use to expand its nuclear weapons arsenal.
The “tilt” towards India that began during the Bush administration has continued under Obama. Only recently, for instance, a State Department official bragged about U.S. progress in selling advanced weaponry to New Delhi. Meanwhile, F-16s that Washington supplied to the Pakistani military back in the heyday of the U.S.-Pakistan alliance may have already been adapted to serve as nuclear delivery vehicles in the event of a nuclear confrontation with India.
China has long adhered to a de facto policy of minimum deterrence—keeping just enough nuclear weapons to dissuade another nation from attacking it with nuclear arms. But this posture has not prevented Beijing from seeking to improve the quality of its long-range ballistic missiles. And if China feels threatened by continued targeting by the U.S. or by sea-based American interceptors deployed to the region, it could easily increase its arsenal to ensure the “safety” of its deterrent. Beijing will also be keeping a watchful eye on India as its nuclear stockpile continues to grow.
Ever since Ronald Reagan—egged on by mad scientists like Edward Teller and right-wing zealots like Lt. Gen. Daniel O. Graham—pledged to build a perfect anti-nuclear shield that would render nuclear weapons “impotent and obsolete,” missile defense has had a powerful domestic constituency in the U.S. This has been the case despite the huge cost and high-profile failures of various iterations of the missile defense concept.
The only concrete achievement of three decades of missile defense research and development so far has been to make Russia suspicious of U.S. intentions. Even now, rightly or not, Russia is extremely concerned about the planned installation of U.S. missile defenses in Europe that Washington insists will be focused on future Iranian nuclear weapons. Moscow feels that they could just as easily be turned on Russia. If President Obama wins a second term, he will undoubtedly hope to finesse this issue and open the door to further joint reductions in nuclear forces, or possibly even consider reducing this country’s nuclear arsenal significantly, whether or not Russia initially goes along.
Recent bellicose rhetoric from Moscow underscores its sensitivity to the missile defense issue, which may yet scuttle any plans for serious nuclear negotiations. Given that the U.S. and Russia together possess more than 90 percent of the world’s nuclear weapons, an impasse between the two nuclear superpowers (even if they are not “super” in other respects) will undercut any leverage they might have to encourage other nations to embark on a path leading to global nuclear reductions.
In his 1960s ode to nuclear proliferation, Who’s Next, Tom Lehrer included the line “Israel’s getting tense, wants one in self-defense.” In fact, Israel was the first—and for now the only—Middle Eastern nation to get the bomb, with reports that it can deliver a nuclear warhead not only from land-based missiles but also via cruise missiles launched from nuclear submarines. Whatever it may say about Israel’s technical capabilities in the military field, Israel’s nuclear arsenal may also be undermining its defense, particularly if it helps spur Iran to build its own nukes. And irresponsible talk by some Israeli officials about attacking Iran only increases the chance that Tehran will decide to go nuclear.
It is hard to handicap the grim, “unthinkable” but hardly inconceivable prospect that August 9, 1945, will not prove to be the last time that nuclear weapons are used on this planet. Perhaps some of the loose nuclear materials or inadequately guarded nuclear weapons littering the globe—particularly, but not solely, in the states of the former Soviet Union—might fall into the hands of a terrorist group. Perhaps an Islamic fundamentalist government will seize power in Pakistan and go a step too far in nuclear brinkmanship with India over Kashmir. Maybe the Israeli leadership will strike out at Iran with nuclear weapons in an effort to keep Tehran from going nuclear. Maybe there will be a miscommunication or false alarm that will result in the U.S. or Russia launching one of their nuclear weapons that are still in Cold War-style, hair-trigger mode.
Although none of these scenarios, including a terrorist nuclear attack, may be as likely as nuclear alarmists sometimes suggest, as long as the world remains massively stocked with nuclear weapons, one of them—or some other scenario yet to be imagined—is always possible. The notion that Iran can’t be trusted with such a weapon obscures a larger point: given their power to destroy life on a monumental scale, no individual and no government can ultimately be trusted with the bomb.
The only way to be safe from nuclear weapons is to get rid of them—not just the Iranian one that doesn’t yet exist, but all of them. It’s a daunting task. It’s also a subject that’s out of the news and off anyone’s agenda at the moment, but if it is ever to be achieved, we at least need to start talking about it. Soon.
Visit EcoWatch's NUCLEAR page for more related news on this topic.
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William D. Hartung is the director of the Arms and Security Project at the Center for International Policy, a TomDispatch regular and the author of Prophets of War: Lockheed Martin and the Making of the Military-Industrial Complex.
Cross-posted with permission from TomDispatch.com.
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A Healthy Microbiome Builds a Strong Immune System That Could Help Defeat COVID-19
By Ana Maldonado-Contreras
Takeaways
- Your gut is home to trillions of bacteria that are vital for keeping you healthy.
- Some of these microbes help to regulate the immune system.
- New research, which has not yet been peer-reviewed, shows the presence of certain bacteria in the gut may reveal which people are more vulnerable to a more severe case of COVID-19.
You may not know it, but you have an army of microbes living inside of you that are essential for fighting off threats, including the virus that causes COVID-19.
How Do Resident Bacteria Keep You Healthy?
<p>Our immune defense is part of a complex biological response against harmful pathogens, such as viruses or bacteria. However, because our bodies are inhabited by trillions of mostly beneficial bacteria, virus and fungi, activation of our immune response is tightly regulated to distinguish between harmful and helpful microbes.</p><p>Our bacteria are spectacular companions diligently helping prime our immune system defenses to combat infections. A seminal study found that mice treated with antibiotics that eliminate bacteria in the gut exhibited an impaired immune response. These animals had low counts of virus-fighting white blood cells, weak antibody responses and poor production of a protein that is vital for <a href="https://doi.org/10.1073/pnas.1019378108" target="_blank">combating viral infection and modulating the immune response</a>.</p><p><a href="https://doi.org/10.1371/journal.pone.0184976" target="_blank" rel="noopener noreferrer">In another study</a>, mice were fed <em>Lactobacillus</em> bacteria, commonly used as probiotic in fermented food. These microbes reduced the severity of influenza infection. The <em>Lactobacillus</em>-treated mice did not lose weight and had only mild lung damage compared with untreated mice. Similarly, others have found that treatment of mice with <em>Lactobacillus</em> protects against different <a href="https://doi.org/10.1038/srep04638" target="_blank" rel="noopener noreferrer">subtypes of</a> <a href="https://doi.org/10.1038/s41598-017-17487-8" target="_blank" rel="noopener noreferrer">influenza</a> <a href="https://doi.org/10.1371/journal.ppat.1008072" target="_blank" rel="noopener noreferrer">virus</a> and human respiratory syncytial virus – the <a href="https://doi.org/10.1038/s41598-019-39602-7" target="_blank" rel="noopener noreferrer">major cause of viral bronchiolitis and pneumonia in children</a>.</p>Chronic Disease and Microbes
<p>Patients with chronic illnesses including Type 2 diabetes, obesity and cardiovascular disease exhibit a hyperactive immune system that fails to recognize a harmless stimulus and is linked to an altered gut microbiome.</p><p>In these chronic diseases, the gut microbiome lacks bacteria that activate <a href="https://doi.org/10.1126/science.1198469" target="_blank" rel="noopener noreferrer">immune cells</a> that block the response against harmless bacteria in our guts. Such alteration of the gut microbiome is also observed in <a href="https://doi.org/10.1073/pnas.1002601107" target="_blank" rel="noopener noreferrer">babies delivered by cesarean section</a>, individuals consuming a poor <a href="https://doi.org/10.1038/nature12820" target="_blank" rel="noopener noreferrer">diet</a> and the <a href="https://doi.org/10.1038/nature11053" target="_blank" rel="noopener noreferrer">elderly</a>.</p><p>In the U.S., 117 million individuals – about half the adult population – <a href="https://health.gov/our-work/food-nutrition/2015-2020-dietary-guidelines/guidelines/" target="_blank" rel="noopener noreferrer">suffer from Type 2 diabetes, obesity, cardiovascular disease or a combination of them</a>. That suggests that half of American adults carry a faulty microbiome army.</p><p>Research in my laboratory focuses on identifying gut bacteria that are critical for creating a balanced immune system, which fights life-threatening bacterial and viral infections, while tolerating the beneficial bacteria in and on us.</p><p>Given that diet affects the diversity of bacteria in the gut, <a href="https://www.umassmed.edu/nutrition/melody-trial-info/" target="_blank" rel="noopener noreferrer">my lab studies show how diet can be used</a> as a therapy for chronic diseases. Using different foods, people can shift their gut microbiome to one that boosts a healthy immune response.</p><p>A fraction of patients infected with SARS-CoV-2, the virus that causes COVID-19 disease, develop severe complications that require hospitalization in intensive care units. What do many of those patients have in common? <a href="https://www.cdc.gov/mmwr/volumes/69/wr/mm6912e2.htm" target="_blank" rel="noopener noreferrer">Old age</a> and chronic diet-related diseases like obesity, Type 2 diabetes and cardiovascular disease.</p><p><a href="http://doi.org/10.1016/j.jada.2008.12.019" target="_blank" rel="noopener noreferrer">Black and Latinx people are disproportionately affected by obesity, Type 2 diabetes and cardiovascular disease</a>, all of which are linked to poor nutrition. Thus, it is not a coincidence that <a href="https://www.cdc.gov/mmwr/volumes/69/wr/mm6933e1.htm" target="_blank" rel="noopener noreferrer">these groups have suffered more deaths from COVID-19</a> compared with whites. This is the case not only in the U.S. but also <a href="https://www.washingtonpost.com/world/europe/blacks-in-britain-are-four-times-as-likely-to-die-of-coronavirus-as-whites-data-show/2020/05/07/2dc76710-9067-11ea-9322-a29e75effc93_story.html" target="_blank" rel="noopener noreferrer">in Britain</a>.</p>Discovering Microbes That Predict COVID-19 Severity
<p>The COVID-19 pandemic has inspired me to shift my research and explore the role of the gut microbiome in the overly aggressive immune response against SARS-CoV-2 infection.</p><p>My colleagues and I have hypothesized that critically ill SARS-CoV-2 patients with conditions like obesity, Type 2 diabetes and cardiovascular disease exhibit an altered gut microbiome that aggravates <a href="https://theconversation.com/exercise-may-help-reduce-risk-of-deadly-covid-19-complication-ards-136922" target="_blank" rel="noopener noreferrer">acute respiratory distress syndrome</a>.</p><p>Acute respiratory distress syndrome, a life-threatening lung injury, in SARS-CoV-2 patients is thought to develop from a <a href="http://doi.org/10.1016/j.cytogfr.2020.05.003" target="_blank" rel="noopener noreferrer">fatal overreaction of the immune response</a> called a <a href="https://theconversation.com/blocking-the-deadly-cytokine-storm-is-a-vital-weapon-for-treating-covid-19-137690" target="_blank" rel="noopener noreferrer">cytokine storm</a> <a href="http://doi.org/10.1016/S2213-2600(20)30216-2" target="_blank" rel="noopener noreferrer">that causes an uncontrolled flood</a> <a href="http://doi.org/10.1016/S2213-2600(20)30216-2" target="_blank" rel="noopener noreferrer">of immune cells into the lungs</a>. In these patients, their own uncontrolled inflammatory immune response, rather than the virus itself, causes the <a href="http://doi.org/10.1007/s00134-020-05991-x" target="_blank" rel="noopener noreferrer">severe lung injury and multiorgan failures</a> that lead to death.</p><p>Several studies <a href="https://doi.org/10.1016/j.trsl.2020.08.004" target="_blank" rel="noopener noreferrer">described in one recent review</a> have identified an altered gut microbiome in patients with COVID-19. However, identification of specific bacteria within the microbiome that could predict COVID-19 severity is lacking.</p><p>To address this question, my colleagues and I recruited COVID-19 hospitalized patients with severe and moderate symptoms. We collected stool and saliva samples to determine whether bacteria within the gut and oral microbiome could predict COVID-19 severity. The identification of microbiome markers that can predict the clinical outcomes of COVID-19 disease is key to help prioritize patients needing urgent treatment.</p><p><a href="https://doi.org/10.1101/2021.01.05.20249061" target="_blank" rel="noopener noreferrer">We demonstrated</a>, in a paper which has not yet been peer reviewed, that the composition of the gut microbiome is the strongest predictor of COVID-19 severity compared to patient's clinical characteristics commonly used to do so. Specifically, we identified that the presence of a bacterium in the stool – called <em>Enterococcus faecalis</em>– was a robust predictor of COVID-19 severity. Not surprisingly, <em>Enterococcus faecalis</em> has been associated with <a href="https://doi.org/10.1053/j.gastro.2011.05.035" target="_blank" rel="noopener noreferrer">chronic</a> <a href="https://doi.org/10.1016/S0002-9440(10)61172-8" target="_blank" rel="noopener noreferrer">inflammation</a>.</p><p><em>Enterococcus faecalis</em> collected from feces can be grown outside of the body in clinical laboratories. Thus, an <em>E. faecalis</em> test might be a cost-effective, rapid and relatively easy way to identify patients who are likely to require more supportive care and therapeutic interventions to improve their chances of survival.</p><p>But it is not yet clear from our research what is the contribution of the altered microbiome in the immune response to SARS-CoV-2 infection. A recent study has shown that <a href="https://doi.org/10.1101/2020.12.11.416180" target="_blank" rel="noopener noreferrer">SARS-CoV-2 infection triggers an imbalance in immune cells</a> called <a href="https://doi.org/10.1111/imr.12170" target="_blank" rel="noopener noreferrer">T regulatory cells that are critical to immune balance</a>.</p><p>Bacteria from the gut microbiome are responsible for the <a href="https://doi.org/10.7554/eLife.30916.001" target="_blank" rel="noopener noreferrer">proper activation</a> <a href="https://doi.org/10.1126/science.1198469" target="_blank" rel="noopener noreferrer">of those T-regulatory</a> <a href="https://doi.org/10.1038/nri.2016.36" target="_blank" rel="noopener noreferrer">cells</a>. Thus, researchers like me need to take repeated patient stool, saliva and blood samples over a longer time frame to learn how the altered microbiome observed in COVID-19 patients can modulate COVID-19 disease severity, perhaps by altering the development of the T-regulatory cells.</p><p>As a Latina scientist investigating interactions between diet, microbiome and immunity, I must stress the importance of better policies to improve access to healthy foods, which lead to a healthier microbiome. It is also important to design culturally sensitive dietary interventions for Black and Latinx communities. While a good-quality diet might not prevent SARS-CoV-2 infection, it can treat the underlying conditions related to its severity.</p><p><em><a href="https://theconversation.com/profiles/ana-maldonado-contreras-1152969" target="_blank">Ana Maldonado-Contreras</a> is an assistant professor of Microbiology and Physiological Systems at the University of Massachusetts Medical School.</em></p><p><em>Disclosure statement: Ana Maldonado-Contreras receives funding from The Helmsley Charitable Trust and her work has been supported by the American Gastroenterological Association. She received The Charles A. King Trust Postdoctoral Research Fellowship. She is also member of the Diversity Committee of the American Gastroenterological Association.</em></p><p><em style="">Reposted with permission from <a href="https://theconversation.com/a-healthy-microbiome-builds-a-strong-immune-system-that-could-help-defeat-covid-19-145668" target="_blank" rel="noopener noreferrer" style="">The Conversation</a>. </em></p>By Jeff Masters, Ph.D.
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