The U.S. Department of Agriculture (USDA) said it will not regulate the potential cultivation and sale of a genetically modified (GMO) mushroom the same way it regulates conventional GMOs because the mushroom was made with the genome-editing tool CRISPR-Cas9.
Thanks to a new gene-editing tool, the common white button mushroom has been genetically altered to resist browning. Photo credit: Flickr
This is the first time the U.S. government has cleared a food product edited with the new and controversial technique.
The USDA announced in a letter last week that it had approved Pennsylvania State University plant pathologist Yinong Yang's common white button mushroom (Agaricus bosporus) that's engineered to be more resistant to browning. As the USDA's Animal and Plant Health Inspection Service (APHIS) wrote on April 13:
The anti-browning trait reduces the formation of brown pigment (melanin), improving the appearance and shelf life of mushroom, and facilitating automated mechanical harvesting.
Based on the information cited in your letter, APHIS has concluded that your CRISPR/Cas9-edited white button mushrooms as described in your letter do not contain any introduced genetic material. APHIS has no reason to believe that CRISPR/Cas9-edited white button mushrooms are plant pests.
According to Nature, the mushroom was created by targeting the family of genes that encodes the enzyme polyphenol oxidase that causes browning. "By deleting just a handful of base pairs in the mushroom’s genome, Yang knocked out one of six PPO genes—reducing the enzyme’s activity by 30 percent," Nature reported.
"If you snip a bit of DNA from a vegetable, but add no new genes, does that vegetable qualify as a GMO?" https://t.co/DH3109Jkar— Farm Aid (@Farm Aid)1460929504.0
So why has this deliberately genetically modified "frankenfungi" escaped USDA scrutiny? Well, instead of the conventional method in which foreign DNA is spliced into a seed (i.e. Bt corn), genetic modification of Yang's mushroom was achieved by altering its own genetic material.
As Quartz explained, a CRISPR-created product falls under a certain loophole:
Despite being directly and purposely genetically modified, USDA has allowed Yang’s mushroom to sidestep the regulatory system. The reason? Yang’s method does not contain “any introduced genetic material” from a plant pest such as bacteria or viruses. Conventional GMOs, the ones that the USDA’s rules are designed to deal with, are created by introducing foreign genes—for example, those of a bacteria might be introduced to give the crop some pest resistance.
Ultimately, the GMO mushroom could be the first of many new CRISPR-edited food products.
“The research community will be very happy with the news," Caixia Gao, a plant biologist at the Chinese Academy of Sciences’s Institute of Genetics and Developmental Biology in Beijing, who was not involved in developing the mushroom, told Nature. "I am confident we'll see more gene-edited crops falling outside of regulatory authority.”
Quartz reported that there are already several CRISPR projects in development, including DuPont's drought-resistant wheat and corn, a banana that can resist a fungus threatening that's threatening its extinction and a herbicide-resistant oilseed from the biotech company Cibus.
“The USDA decision is a perfect illustration of how weak regulations for evaluating genetically engineered crops are,” Patty Lovera of Food & Water Watch, told Quartz.
Absurd! We need new regs to keep up with technology. Gene-edited CRISPR mushroom escapes US regulation https://t.co/wuRejnugbX #gmo #gmos— Max Goldberg (@Max Goldberg)1460944636.0
Wait, what? USDA says it won't regulate this new GMO mushroom: https://t.co/nPLKk7qkve #WhatIsGoingOn #WhyTheChange #NoGMOs— HealthRanger (@HealthRanger)1460905206.0
Yang told Nature he is considering whether or not to bring the mushroom to market.
“I need to talk to my dean about that," he said. "We’ll have to see what the university wants to do next."
Yang, however, told MIT Technology Review that even the company that helped fund the research, Giorgio Mushroom Co. of Pennsylvania, isn't sure if they want the mushroom in a store near you given the public's overwhelming skepticism of GMOs.
“[The] marketing people at Giorgio are more interested in organic mushrooms and are afraid of negative response regarding GMO from consumers,” Yang said.
A 2015 Pew Research Poll revealed that 57 percent of U.S. adults believe that GMO-foods are “generally unsafe” to eat.
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