Glyphosate in Monsanto's Roundup Is Linked to Cancer, But Big Ag Wants it in Your Food Anyway
In Europe, the amount of pesticide residues that are allowed on food is determined by recommendations from the Food and Agriculture Organization of the United Nations (FAO) and the World Health Organization (WHO) at a Joint Meeting on Pesticide Residues (JMPR). Right now their big discussions are all about glyphosate. Glyphosate is the most widely used herbicide in the world and is the main ingredient in the weed killer Roundup, which is applied to more than 150 food and non-food crops. In addition to its agriculture uses, glyphosate is also commonly used on lawns, gardens and parks where pets and kids play.
#Monsanto's beloved #Glyphosate Soon 2Join #Cali #Cancer List: #GMO https://t.co/99fp4yrrcQ http://t.co/bpU0RdkrFO http://t.co/dNfjDhJxBx— Organic Live Food (@Organic Live Food)1442352441.0
Unfortunately, glyphosate is linked to cancer (Group 2A 'probable' human carcinogen) by the International Agency for Research on Cancer (IARC), the prestigious cancer assessment arm of the WHO. But, cancer-causing chemicals have friends in high places. Monsanto is the world's leading producer of glyphosate, with annual sales of Roundup netting about two billion U.S. dollars. Unsurprisingly, the company quickly fired back with a statement on how the company is "outraged" at IARC's "agenda-driven bias" in its "irresponsible" decision-making. [As a side, since IARC announced its decision, a group of U.S. citizens have filed a class action lawsuit against Monsanto for falsifying safety claims and a group of Chinese citizens have filed a lawsuit against the Chinese government for hiding Monsanto's toxicity studies from the public].
In Europe, if a chemical is linked to cancer, then absolutely none of the chemical is allowed to remain as residue on our food. Zero tolerance. That seems reasonable—like zero tolerance for cancer. So, JMPR has assembled a task force to reevaluate IARC's assessment and advise whether or not JMPR's assessment from 2011 should be revised. Natural Resources Defense Council (NRDC) and colleagues sent a letter to JMPR raising two main concerns:
- First, JMPR should not over-turn or attempt to re-do IARC's cancer assessment. IARC's conclusions were the result of an international panel of experts that conducted a comprehensive scientific review of evidence from laboratory animal studies, mechanistic cell studies and epidemiological evidence of cancers in people (see details in a previous blog). IARC found links between non-Hodgkin lymphoma and glyphosate exposure.
- Second, JMPR advisory panel members have financial ties to Big Ag. According to publicly available documents, three of eight panel members have financial and professional ties to the chemical industry, including Monsanto.
Our concerns are further detailed in our letter, which was mailed to the WHO and shared with the public (see press release) on June 29. Unfortunately, our concerns seem to have fallen on deaf ears. The WHO sent us a five paragraph response letter that does little more than acknowledge the receipt of our letter and remind us that the WHO systematically "evaluates any declared interest carefully." No explanation was given to us as to whether or how our particular concerns were taken into consideration.
#Monsanto 😡1st time ever #glyphosate #Roundup willB listed known2cause cancer 👍🏻 #Sacramento http://t.co/dFgH2HEj9j http://t.co/PN2iqI7fwM— They Live News (@They Live News)1442373235.0
JMPR's advisory panel is due to report back to JMPR later this month. How could the financial conflicts of interest not cloud the panel's evaluation of glyphosate's cancer classification? That's why NRDC is concerned that the panel's recommendation to JMPR could seriously undermine IARC's conclusions and result in the continued exposure of the public to glyphosate.
Glyphosate is a non-selective herbicide that kills any plant it comes into contact with, regardless of whether it is a weed or a crop. "Roundup ready" crops, including soy, corn and cotton have been genetically modified to tolerate glyphosate, meaning that farmers can apply as much of the herbicide as they want without worrying about hurting their crops. As a result, glyphosate use has increased tenfold since it was last approved by U.S. Environmental Protection Agency in the early 90s. With the use of glyphosate steadily increasing, it is imperative that JMPR acts to protect the public from being exposed to this probable human carcinogen in their food.
Erik Olson, the director of NRDC's Health Program, nicely sums this all up with the following quote:
"The WHO is highly respected for protecting public health around the world and it should move forward immediately to safeguard people from being harmed by glyphosate. At the same time, the WHO should make absolutely sure that its expert review panel is free of conflicts of interest so it can make science-based evaluations of herbicide and pesticide residues on food and advise what levels are safe for people to be exposed to."
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By Bob Jacobs
Hanako, a female Asian elephant, lived in a tiny concrete enclosure at Japan's Inokashira Park Zoo for more than 60 years, often in chains, with no stimulation. In the wild, elephants live in herds, with close family ties. Hanako was solitary for the last decade of her life.
Hanako, an Asian elephant kept at Japan's Inokashira Park Zoo; and Kiska, an orca that lives at Marineland Canada. One image depicts Kiska's damaged teeth. Elephants in Japan (left image), Ontario Captive Animal Watch (right image), CC BY-ND
Affecting Health and Altering Behavior<p>It is easy to observe the overall health and psychological consequences of life in captivity for these animals. Many captive elephants suffer from arthritis, obesity or skin problems. Both <a href="https://doi.org/10.11609/JoTT.o2620.1826-36" target="_blank">elephants</a> and orcas often have severe dental problems. Captive orcas are plagued by <a href="https://doi.org/10.1016/j.jveb.2019.05.005" target="_blank">pneumonia, kidney disease, gastrointestinal illnesses and infections</a>.</p><p>Many animals <a href="https://doi.org/10.1016/j.neubiorev.2017.09.010" target="_blank">try to cope</a> with captivity by adopting abnormal behaviors. Some develop "<a href="https://doi.org/10.1016/j.applanim.2017.05.003" target="_blank" rel="noopener noreferrer">stereotypies</a>," which are repetitive, purposeless habits such as constantly bobbing their heads, swaying incessantly or chewing on the bars of their cages. Others, especially big cats, pace their enclosures. Elephants rub or break their tusks.</p>
Changing Brain Structure<p>Neuroscientific research indicates that living in an impoverished, stressful captive environment <a href="https://doi.org/10.1016/j.jveb.2019.05.005" target="_blank" rel="noopener noreferrer">physically damages the brain</a>. These changes have been documented in many <a href="https://doi.org/10.1002/cne.903270108" target="_blank" rel="noopener noreferrer">species</a>, including rodents, rabbits, cats and <a href="https://doi.org/10.1006/nimg.2001.0917" target="_blank" rel="noopener noreferrer">humans</a>.</p><p>Although researchers have directly studied some animal brains, most of what we know comes from observing animal behavior, analyzing stress hormone levels in the blood and applying knowledge gained from a half-century of neuroscience research. Laboratory research also suggests that mammals in a zoo or aquarium have compromised brain function.</p>
This illustration shows differences in the brain's cerebral cortex in animals held in impoverished (captive) and enriched (natural) environments. Impoverishment results in thinning of the cortex, a decreased blood supply, less support for neurons and decreased connectivity among neurons. Arnold B. Scheibel, CC BY-ND<p>Subsisting in confined, barren quarters that lack intellectual stimulation or appropriate social contact seems to <a href="https://doi.org/10.1590/S0001-37652001000200006" target="_blank" rel="noopener noreferrer">thin the cerebral cortex</a> – the part of the brain involved in voluntary movement and higher cognitive function, including memory, planning and decision-making.</p><p>There are other consequences. Capillaries shrink, depriving the brain of the oxygen-rich blood it needs to survive. Neurons become smaller, and their dendrites – the branches that form connections with other neurons – become less complex, impairing communication within the brain. As a result, the cortical neurons in captive animals <a href="https://doi.org/10.1002/cne.901230110" target="_blank">process information less efficiently</a> than those living in <a href="https://doi.org/10.1002/dev.420020208" target="_blank">enriched, more natural environments</a>.</p>
An actual cortical neuron in a wild African elephant living in its natural habitat compared with a hypothesized cortical neuron from a captive elephant. Bob Jacobs, CC BY-ND<p>Brain health is also affected by living in small quarters that <a href="https://doi.org/10.3233/BPL-160040" target="_blank">don't allow for needed exercise</a>. Physical activity increases the flow of blood to the brain, which requires large amounts of oxygen. Exercise increases the production of new connections and <a href="http://dx.doi.org/10.1126/science.aaw2622" target="_blank">enhances cognitive abilities</a>.</p><p>In their native habits these animals must move to survive, covering great distances to forage or find a mate. Elephants typically travel anywhere from <a href="https://www.elephantsforafrica.org/elephant-facts/#:%7E:text=How%20far%20do%20elephants%20walk,km%20on%20a%20daily%20basis." target="_blank">15 to 120 miles per day</a>. In a zoo, they average <a href="https://doi.org/10.1371/journal.pone.0150331" target="_blank" rel="noopener noreferrer">three miles daily</a>, often walking back and forth in small enclosures. One free orca studied in Canada swam <a href="https://doi.org/10.1007/s00300-010-0958-x" target="_blank" rel="noopener noreferrer">up to 156 miles a day</a>; meanwhile, an average orca tank is about 10,000 times smaller than its <a href="https://www.cascadiaresearch.org/projects/killer-whales/using-dtags-study-acoustics-and-behavior-southern" target="_blank" rel="noopener noreferrer">natural home range</a>.</p>
Disrupting Brain Chemistry and Killing Cells<p>Living in enclosures that restrict or prevent normal behavior creates chronic frustration and boredom. In the wild, an animal's stress-response system helps it escape from danger. But captivity traps animals with <a href="https://doi.org/10.1073/pnas.1215502109" target="_blank">almost no control</a> over their environment.</p><p>These situations foster <a href="https://doi.org/10.1037/rev0000033" target="_blank">learned helplessness</a>, negatively impacting the <a href="https://doi.org/10.1155/2016/6391686" target="_blank" rel="noopener noreferrer">hippocampus</a>, which handles memory functions, and the <a href="https://doi.org/10.1016/j.neuropharm.2011.02.024" target="_blank" rel="noopener noreferrer">amygdala</a>, which processes emotions. Prolonged stress <a href="https://doi.org/10.3109/10253899609001092" target="_blank" rel="noopener noreferrer">elevates stress hormones</a> and <a href="https://doi.org/10.1523/JNEUROSCI.10-09-02897.1990" target="_blank" rel="noopener noreferrer">damages or even kills neurons</a> in both brain regions. It also disrupts the <a href="https://doi.org/10.1016/j.neubiorev.2005.03.021" target="_blank" rel="noopener noreferrer">delicate balance of serotonin</a>, a neurotransmitter that stabilizes mood, among other functions.</p><p>In humans, <a href="https://doi.org/10.1006/nimg.2001.0917" target="_blank" rel="noopener noreferrer">deprivation</a> can trigger <a href="https://doi.org/10.3389/fnins.2018.00367" target="_blank" rel="noopener noreferrer">psychiatric issues</a>, including depression, anxiety, <a href="https://doi.org/10.3389/fnins.2018.00367" target="_blank" rel="noopener noreferrer">mood disorders</a> or <a href="https://doi.org/10.1177/1073858409333072" target="_blank" rel="noopener noreferrer">post-traumatic stress disorder</a>. <a href="https://doi.org/10.1007/s00429-010-0288-3" target="_blank" rel="noopener noreferrer">Elephants</a>, <a href="https://doi.org/10.1371/journal.pbio.0050139" target="_blank" rel="noopener noreferrer">orcas</a> and other animals with large brains are likely to react in similar ways to life in a severely stressful environment.</p>
Damaged Wiring<p>Captivity can damage the brain's complex circuitry, including the basal ganglia. This group of neurons communicates with the cerebral cortex along two networks: a direct pathway that enhances movement and behavior, and an indirect pathway that inhibits them.</p><p>The repetitive, <a href="http://dx.doi.org/10.1016/j.bbr.2014.05.057" target="_blank">stereotypic behaviors</a> that many animals adopt in captivity are caused by an imbalance of two neurotransmitters, dopamine and <a href="https://doi.org/10.1016/j.neubiorev.2010.02.004" target="_blank" rel="noopener noreferrer">serotonin</a>. This impairs the indirect pathway's ability to modulate movement, a condition documented in species from chickens, cows, sheep and horses to primates and big cats.</p>
The cerebral cortex, hippocampus and amygdala are physically altered by captivity, along with brain circuitry that involves the basal ganglia. Bob Jacobs, CC BY-ND<p>Evolution has constructed animal brains to be exquisitely responsive to their environment. Those reactions can affect neural function by <a href="https://www.penguinrandomhouse.com/books/311787/behave-by-robert-m-sapolsky/" target="_blank">turning different genes on or off</a>. Living in inappropriate or abusive circumstance alters biochemical processes: It disrupts the synthesis of proteins that build connections between brain cells and the neurotransmitters that facilitate communication among them.</p><p>There is strong evidence that <a href="https://doi.org/10.1523/JNEUROSCI.0577-11.2011" target="_blank">enrichment</a>, social contact and appropriate space in more natural habitats are <a href="https://doi.org/10.1111/j.1748-1090.2003.tb02071.x" target="_blank" rel="noopener noreferrer">necessary</a> for long-lived animals with large brains such as <a href="https://doi.org/10.1371/journal.pone.0152490" target="_blank" rel="noopener noreferrer">elephants</a> and <a href="https://doi.org/10.1080/13880292.2017.1309858" target="_blank" rel="noopener noreferrer">cetaceans</a>. Better conditions <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5543669/" target="_blank" rel="noopener noreferrer">reduce disturbing sterotypical behaviors</a>, improve connections in the brain, and <a href="https://doi.org/10.1038/cdd.2009.193" target="_blank" rel="noopener noreferrer">trigger neurochemical changes</a> that enhance learning and memory.</p>