Environmentally-Caused Disease Crisis? Pesticide Damage to DNA Found 'Programmed' Into Future Generations
When Dr. Paul Winchester, a pediatrician, moved to Indiana from Colorado in 2002, he noticed something disturbing—a high number of birth defects.
"I was used to the number of birth defects I should see in a community hospital, and I saw many more in Indiana," said Winchester, who is medical director of the Neonatal and Intensive Care Unit at St. Francis Hospital in Indianapolis.
Winchester decided to investigate the reason for the higher numbers of birth defects. His research zeroed in on the herbicide atrazine, one of the most widely used herbicides in the U.S. and the most commonly detected pesticide in U.S. drinking water.
Winchester and several other researchers including Michael Skinner, professor of biology at Washington State University's Center for Reproductive Biology, conducted a study to see if there was a link between atrazine in drinking water and birth defects.
Studies have found that atrazine is an endocrine disruptor, a substance that can alter the human hormonal system. Atrazine was banned by the European Union because of its persistent groundwater contamination.
In their study, Winchester and his team found that concentrations of atrazine in drinking water were highest in May and June when farmers sprayed their fields with the herbicide. They also found that birth defects peaked during the same months indicating a close correlation.
"We plotted water concentrations and birth defects, and they fit like a hat," Winchester said.
Their study, which was funded by the Gerber Foundation, was published in 2017 on PLOS One.
Epigenetic Changes Programmed Into Future Generations
But the most disturbing finding was that atrazine had epigenetic effects. Epigenetics is the theory that environmental factors, such as diet, lifestyle choices and pesticides can impact the health of people who are exposed to them and also their descendants. Human DNA, according to epigenetics, is not unchangeable; it can be altered by such environmental factors. Epigenetic changes can be imprinted on the DNA of a fetus during pregnancy according to Winchester.
"If it is fixed then, it becomes inheritable and it becomes a trait that you can pass on to the next generation and the next and next."
Epigenetics is a fairly new concept that is slowly gaining acceptance.
"This is a really important concept that is difficult to teach the public, and when I say the public I include my clinical colleagues," Winchester said.
For the atrazine study, Winchester's team used Skinner's advanced technology to detect epigenetic changes—and resulting negative health impacts—over several generations of rats whose mothers were exposed to atrazine.
Common sense would seem to dictate that fewer negative health outcomes would be seen with subsequent generations. But the study found the opposite: There were more abnormalities and diseases in later generations of rats. The first generation of rats whose mother was exposed to atrazine weighed less than a group of control rats. The second generation weighed less but also had incidences of testicular disease and breast cancer. The third generation suffered the most problems, according to Winchester.
"We waited until the third generation, where no direct exposure (to atrazine) occurred, to ask if these epigenetic effects could be inherited, because there is no mechanism, no exposure, no toxicity that could explain a change in disease rates in the third generation. We found that 50 percent of offspring had multiple diseases, emotional and physical problems, hyperactivity, abnormal sperm, and premature puberty."
In an earlier study, Skinner found that the fungicide vinclozolin also caused inheritable diseases in rats. In all, he tested nearly 20 chemicals and found that all produce epigenetic effects, said Winchester.
"The most alarming (finding) to me is that almost every chemical tested including atrazine reduced fertility in the third generation of offspring."
Winchester called the discovery of the link between chemicals like pesticides and epigenetic changes leading to disease "the most important next discovery in all of medicine."
"What we are learning is that virtually every adult disease we have is going to be linked to epigenetic origins as well," he said.
More research needs to be done on the link between epigenetic effects and disease but Winchester says limited funding is available for such research.
"This is a huge thing that is going to change how we understand the origin of disease. But a big part of that is that it will change our interpretation of what chemicals are safe. In medicine I can't give a drug to somebody unless it has gone through a huge amount of testing. But all these chemicals haven't gone through anything like that. We've been experimented on for the last 70 years, and there's not one study on multigenerational effects."
Glyphosate Levels in Mothers Linked to Shorter Pregnancies
Winchester also co-authored a study published recently in Environmental Health that found detectable levels of glyphosate in the urine of 93 percent of a group of pregnant women in Central Indiana. The levels of glyphosate detected correlated with shorter pregnancies.
Again, the study raises concerns of possible epigenetic effects leading to disease in later generations.
"We are the first researchers in the U.S. to report that virtually every pregnant mother has glyphosate in her body at the time that she is creating fetal (epigenetic) imprints in her baby," Winchester said.
Winchester and his team focused on atrazine and glyphosate because they are the most heavily used pesticides in the U.S.
"That's the only reason they were chosen. We looked to see how commonly they are found in pregnant women, and we were mortified."
Winchester has been surprised by the lack of reaction to the glyphosate study.
"A chemical (glyphosate) that didn't come onto the scene until the 1970s has now managed to find its way into every single pregnant woman in the U.S, except seven percent of them. We thought that should be news. But in the current paradigm, which is definitely pro-business, the only thing companies have to prove is that it doesn't kill you if you drink it or take a big dose of it."
He sees a potentially catastrophic outcome resulting from the epigenetic damage caused by pesticides.
"Every one of the chemicals tested so far produces infertility, and the industrial world has reached the lowest level of fertility on record. We are below replacement levels in most industrialized countries including the U.S.This is looking at your own species extinction."
Winchester lays the blame at the feet of the U.S. Environmental Protection Agency, which doesn't consider epigenetic or generational effects of chemicals, and the pesticide and chemical manufacturers like Monsanto.
"They can sell all the Roundup they want, but if it's in me they are going to have to pay for that. Every molecule that I find is on them … What I want to know is: has my fetus had altered DNA imprinting because of this chemical? I have a right to know that. If we are going to have to wait 75 years to find out if my grandchildren are going to be affected by it, I think somebody has to pay. They better put a fund together. I want somebody's head to roll. I don't think that the EPA and Monsanto get to walk away."
Winchester connects an ancient expression to a modern health crisis.
"Even in the Bible, there is the saying, 'the sins of the father are visited upon his offspring.' Well, it turns out that they are."
EcoWatch Daily Newsletter
The chance that UK summer days could hit the 40 degree Celsius mark on the thermometer is on the rise, a new study from the country's Met Office Hadley Centre has found.
- As Extreme Weather Turns Deadly in the UK, Climate Activists Are ... ›
- UK Parliament First in World to Declare Climate Emergency ... ›
By Melissa Hawkins
After sustained declines in the number of COVID-19 cases over recent months, restrictions are starting to ease across the United States. Numbers of new cases are falling or stable at low numbers in some states, but they are surging in many others. Overall, the U.S. is experiencing a sharp increase in the number of new cases a day, and by late June, had surpassed the peak rate of spread in early April.
Seven day rolling average of number of people confirmed to have COVID-19, per day (not including today). This chart gets updated once per day with data by Johns Hopkins. Johns Hopkins university doesn't provide reliable data for March 12 and March 13. Johns Hopkins CSSE Get the data
To Have a Second Wave, the First Wave Needs to End.<p>A wave of an infection describes a large rise and fall in the number of cases. There isn't a precise epidemiological definition of when a wave begins or ends.</p><p>But with talk of a <a href="https://www.theguardian.com/world/2020/jun/27/new-covid-19-clusters-across-world-spark-fear-of-second-wave" target="_blank">second wave in the news</a>, as an <a href="https://www.american.edu/cas/faculty/mhawkins.cfm" target="_blank">epidemiologist and public health researcher</a>, I think there are two necessary factors that must be met before we can colloquially declare a second wave.</p><p>First, the virus would have to be controlled and transmission brought down to a very low level. That would be the end of the first wave. Then, the virus would need to reappear and result in a large increase in cases and hospitalizations.</p><p>Many countries in <a href="https://doi.org/10.1038/s41562-020-0908-8" target="_blank">Europe and Asia have successfully ended the first wave</a>. <a href="https://www.theguardian.com/world/2020/jun/08/new-zealand-abandons-covid-19-restrictions-after-nation-declared-no-cases" target="_blank">New Zealand</a> and <a href="https://www.newyorker.com/magazine/2020/06/08/how-iceland-beat-the-coronavirus" target="_blank">Iceland</a> have also made it through their first waves and are now essentially coronavirus-free, with very low levels of community transmission and only a handful of active cases currently.</p>
Different States, Different Trends<p>Looking at U.S. numbers as a whole hides what is really going on. Different states are in <a href="https://www.nytimes.com/interactive/2020/us/coronavirus-us-cases.html" target="_blank">vastly different situations right now</a> and when you look at states individually, four major categories emerge.</p><ol><li>Places where the first wave is ending: States in the Northeast and a few scattered elsewhere experienced large initial spikes but were able to mostly contain the virus and substantially brought down new infections. <a href="https://www.nytimes.com/interactive/2020/us/new-york-coronavirus-cases.html" target="_blank">New York</a> is a good example of this.</li><li>Places still in the first wave: Several states in the South and West – see <a href="https://www.nytimes.com/interactive/2020/us/texas-coronavirus-cases.html" target="_blank">Texas</a> and <a href="https://www.nytimes.com/interactive/2020/us/california-coronavirus-cases.html" target="_blank">California</a> – had some cases early on, but are now seeing massive surges with no sign of slowing down.</li><li>Places in between: Many states were hit early in the first wave, managed to slow it down, but are either at a plateau – like <a href="https://www.nytimes.com/interactive/2020/us/north-dakota-coronavirus-cases.html" target="_blank">North Dakota</a> – or are now seeing steep increases – like <a href="https://www.nytimes.com/interactive/2020/us/oklahoma-coronavirus-cases.html" target="_blank">Oklahoma</a>.</li><li>Places experiencing local second waves: Looking only at a state level, <a href="https://www.nytimes.com/interactive/2020/us/hawaii-coronavirus-cases.html" target="_blank">Hawaii</a>, <a href="https://www.nytimes.com/interactive/2020/us/montana-coronavirus-cases.html" target="_blank">Montana</a> and <a href="https://www.nytimes.com/interactive/2020/us/alaska-coronavirus-cases.html" target="_blank">Alaska</a> could be said to be experiencing second waves. Each state experienced relatively small initial outbreaks and was able to reduce spread to single digits of daily new confirmed cases, but are now all seeing spikes again.</li></ol><p>The trends aren't surprising based on how states have been dealing with reopening. The virus will go wherever there are susceptible people and until the U.S. stops community spread across the entire country, the first wave isn't over.</p>
What Could a Second Wave Look Like?<p>It is possible – though at this point it seems unlikely – that the U.S. could control the virus before a vaccine is developed. If that happens, it would be time to start thinking about a second wave. The question of what it might look like depends in large part on everyone's actions.</p><p>The <a href="https://dx.doi.org/10.1086%2F592454" target="_blank">1918 flu pandemic</a> was characterized by a mild first wave in the winter of 1917-1918 that went away in summer. After restrictions were lifted, people very quickly went back to pre-pandemic life. But a second, deadlier strain came back in fall of 1918 and third in spring of 1919. In total, <a href="https://www.cdc.gov/flu/pandemic-resources/1918-commemoration/1918-pandemic-history.htm" target="_blank">more than 500 million people were infected</a> worldwide and upwards of <a href="https://theconversation.com/compare-the-flu-pandemic-of-1918-and-covid-19-with-caution-the-past-is-not-a-prediction-138895" target="_blank">50 million died</a> over the course of three waves.</p><p>It was the combination of a quick return to normal life and a mutation in the flu's genome that made it more deadly that led to the horrific second and third waves.</p><p>Thankfully, the coronavirus appears to be much more <a href="https://doi.org/10.1016/j.meegid.2020.104351" target="_blank">genetically stable</a> than the influenza virus, and thus less likely to mutate into a more deadly variant. That leaves human behavior as the main risk factor.</p><p>Until a <a href="https://theconversation.com/what-needs-to-go-right-to-get-a-coronavirus-vaccine-in-12-18-months-136816" target="_blank">vaccine or effective treatment is developed</a>, the tried-and-true public health measures of the last months – <a href="https://theconversation.com/this-simple-model-shows-the-importance-of-wearing-masks-and-social-distancing-140423" target="_blank">social distancing,</a> <a href="https://theconversation.com/masks-help-stop-the-spread-of-coronavirus-the-science-is-simple-and-im-one-of-100-experts-urging-governors-to-require-public-mask-wearing-138507" target="_blank">universal mask wearing</a>, frequent hand-washing and avoiding crowded indoor spaces – are the ways to stop the first wave and thwart a second one. And when there are surges like what is happening now in the U.S., further reopening plans need to be put on hold.</p>
- U.S. Coronavirus Death Toll Now No. 1 in World - EcoWatch ›
- U.S. Coronavirus Deaths Pass 100,000 - EcoWatch ›
- U.S. Coronavirus Cases Top 2 Million as All 50 States Start ... ›
By Eoin Higgins
Climate advocates pointed to news Sunday that fracking giant Chesapeake Energy was filing for bankruptcy as further evidence that the fossil fuel industry's collapse is being hastened by the coronavirus pandemic and called for the government to stop propping up businesses in the field.
- Fracking Industry's Propaganda Hypes Shale Gas Production and ... ›
- Another Blow to the Fracking Industry—Chesapeake Energy's ... ›
- Former Chesapeake Energy CEO Aubrey McClendon Is Back to ... ›
By Neil King and Gabriel Borrud
Human beings all over the world agreed to strict limitations to their rights when governments made the decision to enter lockdown during the COVID-19 crisis. Many have done it willingly on behalf of the collective. So why can't this same attitude be seen when tackling climate change?
- The Crunch Question on Climate: How Can I Help? - EcoWatch ›
- The Power of Collective Action Gangnam Style - EcoWatch ›
- Scientist Finds Remarkable Way to Connect People Emotionally ... ›
Fire experts have already criticized President Trump's planned fireworks event for this Friday at Mt. Rushmore National Memorial as a dangerous idea. Now, it turns out the event may be socially irresponsible too as distancing guidelines and mask wearing will not be enforced at the event, according to CNN.
- Trump's Fireworks Show at Mt. Rushmore Is a Dangerous Idea, Fire ... ›
- Attendees at Trump's First Rally Since March Can't Sue if They Get ... ›
By Emma Charlton
Gluts of food left to rot as a consequence of coronavirus aren't just wasteful – they're also likely to damage the environment.
Methane on the Rise<p>Not only is this a tragic waste of food at a time when many are going hungry, it is also an <a href="https://donatedontdump.net/2014/07/07/the-effects-of-food-waste-on-the-environment-by-junemy-pantig/" target="_blank">environmental hazard</a> and could contribute to global warming. Landfill gas – <a href="https://www.epa.gov/lmop/basic-information-about-landfill-gas" target="_blank">roughly half methane and half carbon dioxide (CO2)</a> – is a natural byproduct of the decomposition of organic material.</p>
Food decay leads to production of greenhouse gases, methane and carbon dioxide. EPA<p>Methane is a potent greenhouse gas, 28 to <a href="https://www.ipcc.ch/site/assets/uploads/2018/02/SYR_AR5_FINAL_full.pdf" target="_blank">36 times more effective than CO2 at trapping heat</a> in the atmosphere over a 100-year period, according to the Intergovernmental Panel on Climate Change.</p><p>"Many export-oriented producers produce volumes far too large for output to be absorbed in local markets, and thus <a href="https://unctad.org/en/pages/newsdetails.aspx?OriginalVersionID=2333" target="_blank">organic waste levels have mounted substantially</a>," says Robert Hamwey, Economic Affairs Officer at UN agency UNCTAD. "Because this waste is left to decay, levels of methane emissions, a greenhouse gas, from decaying produce are expected to rise sharply in the crisis and immediate post-crisis months."</p>
Food supply chains are easily disrupted. UN FAO<p>Dumping food was already a problem before the crisis. In America alone, <a href="https://www.refed.com/?sort=economic-value-per-ton" target="_blank">$218 billion is spent growing, processing, transporting</a> and disposing of food that is never eaten, estimates ReFED, a collection of business, non-profit and government leaders committed to reducing food waste. That's equivalent to around 1.3% of GDP.</p><p>Since the pandemic took hold, <a href="https://www.bbc.co.uk/news/world-52267943" target="_blank">farmers are dumping 14 million liters</a> of milk each day because of disrupted supply routes, estimates Dairy Farmers of America. A chicken processor was forced to <a href="https://www.nytimes.com/2020/04/11/business/coronavirus-destroying-food.html" target="_blank">destroy 750,000 unhatched eggs a week</a>, according to the New York Times, which also cited an onion farmer letting most of his harvest decompose because he couldn't distribute or store them.</p>
Food Prices Collapsing<p>The excess has also seen prices collapse. The <a href="http://www.fao.org/worldfoodsituation/foodpricesindex/en/" target="_blank">FAO Food Price Index</a> (FFPI) averaged 162.5 points in May 2020, down 3.1 points from April and reaching the lowest monthly average since December 2018. The gauge has dropped for four consecutive months, and the latest decline reflects falling values of all the food commodities – dairy, meat, cereal, vegetable – except sugar, which rose for the first time in three months.</p><p>All this while the pandemic is exacerbating other global food trends.</p><p>"This year, some 49 million extra people may fall into extreme poverty due to the COVID-19 crisis," said António Guterres, Secretary-General of the UN. "The number of people who are acutely food or nutrition insecure will rapidly expand. <a href="https://www.youtube.com/watch?v=fGhLKAbNDiY&feature=youtu.be" target="_blank">Even in countries with abundant food, we see risks of disruptions in the food supply chain</a>."</p>
- Food Waste Set to Increase by 33 Percent Within 10 Years - EcoWatch ›
- Reducing Food Waste Is Good for Economy and Climate, Report Says ›
- 23 Organizations Eliminating Food Waste During COVID-19 ... ›
Puerto Rico's governor declared a state of emergency on Monday after a severe drought on the island left 140,000 people without access to running water, despite the necessary role that hand washing and hygiene plays in stopping the novel coronavirus, as The Independent reported.
- When the Government Failed Puerto Rico, Local Communities ... ›
- Latino Voters Worried About Climate Change Could Swing 2020 ... ›