Environmentally-Caused Disease Crisis? Pesticide Damage to DNA Found 'Programmed' Into Future Generations
When Dr. Paul Winchester, a pediatrician, moved to Indiana from Colorado in 2002, he noticed something disturbing—a high number of birth defects.
"I was used to the number of birth defects I should see in a community hospital, and I saw many more in Indiana," said Winchester, who is medical director of the Neonatal and Intensive Care Unit at St. Francis Hospital in Indianapolis.
Winchester decided to investigate the reason for the higher numbers of birth defects. His research zeroed in on the herbicide atrazine, one of the most widely used herbicides in the U.S. and the most commonly detected pesticide in U.S. drinking water.
Winchester and several other researchers including Michael Skinner, professor of biology at Washington State University's Center for Reproductive Biology, conducted a study to see if there was a link between atrazine in drinking water and birth defects.
Studies have found that atrazine is an endocrine disruptor, a substance that can alter the human hormonal system. Atrazine was banned by the European Union because of its persistent groundwater contamination.
In their study, Winchester and his team found that concentrations of atrazine in drinking water were highest in May and June when farmers sprayed their fields with the herbicide. They also found that birth defects peaked during the same months indicating a close correlation.
"We plotted water concentrations and birth defects, and they fit like a hat," Winchester said.
Their study, which was funded by the Gerber Foundation, was published in 2017 on PLOS One.
Epigenetic Changes Programmed Into Future Generations
But the most disturbing finding was that atrazine had epigenetic effects. Epigenetics is the theory that environmental factors, such as diet, lifestyle choices and pesticides can impact the health of people who are exposed to them and also their descendants. Human DNA, according to epigenetics, is not unchangeable; it can be altered by such environmental factors. Epigenetic changes can be imprinted on the DNA of a fetus during pregnancy according to Winchester.
"If it is fixed then, it becomes inheritable and it becomes a trait that you can pass on to the next generation and the next and next."
Epigenetics is a fairly new concept that is slowly gaining acceptance.
"This is a really important concept that is difficult to teach the public, and when I say the public I include my clinical colleagues," Winchester said.
For the atrazine study, Winchester's team used Skinner's advanced technology to detect epigenetic changes—and resulting negative health impacts—over several generations of rats whose mothers were exposed to atrazine.
Common sense would seem to dictate that fewer negative health outcomes would be seen with subsequent generations. But the study found the opposite: There were more abnormalities and diseases in later generations of rats. The first generation of rats whose mother was exposed to atrazine weighed less than a group of control rats. The second generation weighed less but also had incidences of testicular disease and breast cancer. The third generation suffered the most problems, according to Winchester.
"We waited until the third generation, where no direct exposure (to atrazine) occurred, to ask if these epigenetic effects could be inherited, because there is no mechanism, no exposure, no toxicity that could explain a change in disease rates in the third generation. We found that 50 percent of offspring had multiple diseases, emotional and physical problems, hyperactivity, abnormal sperm, and premature puberty."
In an earlier study, Skinner found that the fungicide vinclozolin also caused inheritable diseases in rats. In all, he tested nearly 20 chemicals and found that all produce epigenetic effects, said Winchester.
"The most alarming (finding) to me is that almost every chemical tested including atrazine reduced fertility in the third generation of offspring."
Winchester called the discovery of the link between chemicals like pesticides and epigenetic changes leading to disease "the most important next discovery in all of medicine."
"What we are learning is that virtually every adult disease we have is going to be linked to epigenetic origins as well," he said.
More research needs to be done on the link between epigenetic effects and disease but Winchester says limited funding is available for such research.
"This is a huge thing that is going to change how we understand the origin of disease. But a big part of that is that it will change our interpretation of what chemicals are safe. In medicine I can't give a drug to somebody unless it has gone through a huge amount of testing. But all these chemicals haven't gone through anything like that. We've been experimented on for the last 70 years, and there's not one study on multigenerational effects."
Glyphosate Levels in Mothers Linked to Shorter Pregnancies
Winchester also co-authored a study published recently in Environmental Health that found detectable levels of glyphosate in the urine of 93 percent of a group of pregnant women in Central Indiana. The levels of glyphosate detected correlated with shorter pregnancies.
Again, the study raises concerns of possible epigenetic effects leading to disease in later generations.
"We are the first researchers in the U.S. to report that virtually every pregnant mother has glyphosate in her body at the time that she is creating fetal (epigenetic) imprints in her baby," Winchester said.
Winchester and his team focused on atrazine and glyphosate because they are the most heavily used pesticides in the U.S.
"That's the only reason they were chosen. We looked to see how commonly they are found in pregnant women, and we were mortified."
Winchester has been surprised by the lack of reaction to the glyphosate study.
"A chemical (glyphosate) that didn't come onto the scene until the 1970s has now managed to find its way into every single pregnant woman in the U.S, except seven percent of them. We thought that should be news. But in the current paradigm, which is definitely pro-business, the only thing companies have to prove is that it doesn't kill you if you drink it or take a big dose of it."
He sees a potentially catastrophic outcome resulting from the epigenetic damage caused by pesticides.
"Every one of the chemicals tested so far produces infertility, and the industrial world has reached the lowest level of fertility on record. We are below replacement levels in most industrialized countries including the U.S.This is looking at your own species extinction."
Winchester lays the blame at the feet of the U.S. Environmental Protection Agency, which doesn't consider epigenetic or generational effects of chemicals, and the pesticide and chemical manufacturers like Monsanto.
"They can sell all the Roundup they want, but if it's in me they are going to have to pay for that. Every molecule that I find is on them … What I want to know is: has my fetus had altered DNA imprinting because of this chemical? I have a right to know that. If we are going to have to wait 75 years to find out if my grandchildren are going to be affected by it, I think somebody has to pay. They better put a fund together. I want somebody's head to roll. I don't think that the EPA and Monsanto get to walk away."
Winchester connects an ancient expression to a modern health crisis.
"Even in the Bible, there is the saying, 'the sins of the father are visited upon his offspring.' Well, it turns out that they are."
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EcoWatch Daily Newsletter
By Mark Hertsgaard
What follows are not candidate endorsements. Rather, this nonpartisan guide aims to inform voters' choices, help journalists decide what races to follow, and explore what the 2020 elections could portend for climate action in the United States in 2021 and beyond.
Will the White House Turn Green?<p>Whether the White House changes hands is the most important climate question of the 2020 elections. President Donald Trump rejects climate science, is withdrawing the United States from the Paris Agreement, and has accelerated fossil fuel development. His climate policy seems to be, as he tweeted in January when rejecting a U.S. Army Corps of Engineers proposal to protect New York City from storm surges, "Get your mops and buckets ready."</p><p>Joe Biden, who started the 2020 campaign with a climate position so weak that activists gave it an "F," called Trump a "climate arsonist" during California's recent wildfires. Biden backs a $2 trillion plan to create millions of jobs while slashing emissions—a Green New Deal in all but name. Equally striking, his running mate, California Senator Kamala Harris, has endorsed phasing out fossil fuel production—a politically explosive scientific imperative.</p><p>The race will be decided in a handful of battleground states, five of which already face grave climate dangers: Florida (hurricanes and sea-level rise), North Carolina (ditto), Texas (storms and drought), Michigan (floods), and Arizona (heat waves and drought). <a href="https://climatecommunication.yale.edu/visualizations-data/ycom-us/" target="_blank">Public concern is rising</a> in these states, but will that concern translate into votes?</p>
Will Democrats Flip the Senate, and by Enough to Pass a Green New Deal?<p>With Democrats all but certain to maintain their majority in the U.S. House of Representatives, the Senate will determine whether a potential Biden administration can actually deliver climate progress. Democrats need to pick up three seats to flip the Senate if Biden wins, four if he doesn't. But since aggressive climate policy is shunned by some Democrats, notably Joe Manchin of coal-dependent West Virginia, Democrats probably need to gain five or six Senate seats to pass a Green New Deal.</p><p>Environmentalists, including the League of Conservation Voters, are targeting six Republicans who polls suggest are vulnerable.</p><ul><li>Steve Daines of Montana, who denies climate science</li><li>Martha McSally of Arizona</li><li>Thom Tillis of North Carolina</li><li>Susan Collins of Maine</li><li>Joni Ernst of Iowa (bankrolled by Charles Koch)</li><li>John James of Michigan (also a Koch beneficiary)</li></ul><p>Republican Senators are even at risk in conservative Kansas and Alaska. In both states, the Democratic candidates are physicians—not a bad credential amid a pandemic—who support climate action. In Kansas, Barbara Bollier faces an incumbent funded by Charles Koch. In Alaska, Al Gross urges a transition away from oil, though his openness to limited drilling in the Arctic National Wildlife Preserve dims his appeal to green groups. He faces incumbent Republican Dan Sullivan, who receives an 8 percent lifetime voting record from the League of Conservation Voters.</p>
Will Local and State Races Advance Climate Progress?<h4>THE CLIMATE HAWKS</h4><p>Under Democratic and Republican leadership alike, Washington has long been a graveyard for strong climate action. But governors can boost or block renewable energy; the Vermont and New Hampshire races are worth watching. Attorneys general can sue fossil fuel companies for lying about climate change; climate hawks are running for the top law enforcement seats in Montana and North Carolina. State legislatures can accelerate or delay climate progress, as the new Democratic majorities in Virginia have shown. Here, races to watch include Pennsylvania, North Carolina, and Colorado.</p><h4>THE CLIMATE POLICY MAKERS</h4><p>Perhaps the most powerful, and most overlooked, climate policy makers are public utility commissions. They control whether pipelines and other energy infrastructure gets built; they regulate whether electric utilities expand solar and energy efficiency or stick with the carbon-heavy status quo. Regulatory capture and outright corruption are not uncommon.</p><p>A prime example is Arizona, where a former two-term commissioner known as the godfather of solar in the state is seeking a comeback. Bill Mundell argues that since Arizona law permits utilities to contribute to commissioners' electoral campaigns, the companies can buy their own regulators. Which may explain why super-sunny Arizona has so little installed solar capacity.</p><p>In South Dakota, Remi Bald Eagle, a Native American U.S. Army veteran, seeks a seat on the South Dakota Public Utilities Commission, which rules on the Standing Rock oil pipeline. And in what <em>HuffPost</em> called "the most important environmental race in the country," Democrat Chrysta Castaneda, who favors phasing out oil production, is running for the Texas Railroad Commission, which despite its name decides what oil, gas, and electric companies in America's leading petro-state can build.</p>
Will the Influencers Usher in a Green New Era?<h4>THE UNCOUNTED</h4><p>The story that goes largely under-reported in every U.S. election is how few Americans vote. In 2016, some 90 million, <a href="https://www.pewresearch.org/politics/2018/08/09/an-examination-of-the-2016-electorate-based-on-validated-voters/" target="_blank" rel="noopener noreferrer">roughly four out of every 10 eligible voters</a>, did not cast a ballot. Attorney Nathaniel Stinnett claims that 10 million of these nonvoters nevertheless identify as environmentalists: They support green policies, even donate to activist groups; they just don't vote. Stinnett's <a href="https://www.environmentalvoter.org/" target="_blank" rel="noopener noreferrer">Environmental Voter Project</a> works to awaken this sleeping giant.</p><h4>THE SUNRISE MOVEMENT</h4><p>Meanwhile, the young climate activists of the <a href="http://www.sunrisemovement.org/" target="_blank" rel="noopener noreferrer">Sunrise Movement</a> are already winning elections with an unabashedly Green New Deal message. More than any other group, Sunrise pushed the Green New Deal into the national political conversation, helping Representative Alexandria Ocasio-Cortez and Senator Ed Markey draft the eponymous congressional resolution. In 2020, Sunrise has helped Green New Deal champions defeat centrists in Democratic primaries, with Markey dealing Representative Joe Kennedy Jr. the first defeat a Kennedy has ever suffered in a Massachusetts election. But can Sunrise also be successful against Republicans in the general elections this fall?</p><h4>THE STARPOWER</h4><p>And an intriguing wild card: celebrity firepower, grassroots activism, and big-bucks marketing have converged behind a campaign to get Latina mothers to vote climate in 2020. Latinos have long been the U.S. demographic most concerned about climate change. Now, <a href="https://votelikeamadre.com/" target="_blank" rel="noopener noreferrer">Vote Like A Madre</a> aims to get 5 million Latina mothers in Florida, Texas, and Arizona to the polls. Jennifer Lopez, Salma Hayak, and Lin-Manuel Miranda are urging mothers to make a "pinky promise" to vote for their kids' climate future in November. Turning out even a quarter of those 5 million voters, though no easy task, could swing the results in three states Trump must win to remain president, which brings us back to the first category, "Will the White House Turn Green?"</p>
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By Tony Carnie
South Africa is home to around 1,300 of the world's roughly 7,100 remaining cheetahs. It's also the only country in the world with significant cheetah population growth, thanks largely to a nongovernmental conservation project that depends on careful and intensive human management of small, fenced-in cheetah populations. Because most of the reserves are privately funded and properly fenced, the animals benefit from higher levels of security than in the increasingly thinly funded state reserves.
Vincent van der Merwe at a cheetah translocation. Endangered Wildlife Trust
Under Pressure<p>Cheetah populations elsewhere in Southern Africa have not prospered over the past 50 years. In Zimbabwe, cheetah numbers have crashed from 1,500 in 1975, to just 170 today. Botswana's cheetah population has held steady at around 1,500 over the same period, but illegal capture for captive breeding and conflicts with farmers and the growing human population are increasing. In Namibia, there were an estimated 3,000 cheetah in in 1975; roughly 1,400 remain today.</p><p>In contrast, South Africa's cheetah numbers have grown from about 500 in 1975 to nearly 1,300 today. Van der Merwe, who is also a Ph.D. student at the University of Cape Town's Institute for Communities and Wildlife in Africa (iCWild), says he's confident that South Africa will soon overtake Namibia and Botswana, largely because the majority of South African cheetahs are protected and managed behind fences, whereas most of the animals in the neighboring countries remain more vulnerable on mainly unfenced lands.</p><p>Wildlife researchers Florian Weise and colleagues have reported that private stock owners in Namibia still trap cheetahs mainly for translocation, but there are few public or private reserves large enough to contain them. Weise says that conservation efforts need to focus on improving tolerance toward cheetahs in commercial livestock and game farming areas to reduce indiscriminate trapping.</p><p>Van der Merwe says fences can be both a blessing and a curse. While these barriers prevent cheetahs and other wild animals from migrating naturally to breed and feed, they also protect cheetahs from the growing tide of threats from humanity and agriculture.</p><p>To simulate natural dispersion patterns that guard against inbreeding, the trust helps landowners swap their animals with other cheetah reserves elsewhere in the country. The South African metapopulation project has been so successful in boosting numbers that the trust is having to look beyond national boundaries to secure new translocation areas in Malawi, Zambia and Mozambique.</p><p>Cheetah translocations have been going on in South Africa since the mid-1960s, when the first unsuccessful attempts were made to move scores of these animals from Namibia. These relocations were mostly unsuccessful.</p>
Charli de Vos uses a VHF antenna to locate cheetahs in Phinda Game Reserve. Tony Carnie for Mongabay
Swinging for the Fences<p>But other wildlife conservation leaders have a different perspective on cheetah conservation strategy.</p><p>Gus Mills, a senior carnivore researcher retired in 2006 from SANParks, the agency that manages South Africa's national parks, after a career of more than 30 years in Kalahari and Kruger national parks. He says the focus should be on quality of living spaces rather than the quantity of cheetahs.</p><p>Mills, who was the founder of the Endangered Wildlife Trust's Carnivore Conservation Group in 1995, and who also spent six years after retirement studying cheetahs in the Kalahari, says it's more important to properly protect and, where possible, expand the size of existing protected areas.</p><p>He also advocates a triage approach to cheetah conservation, in which scarce funds and resources are focused on protecting cheetahs in formally protected areas, rather than diluting scarce resources in an attempt to try and save every single remaining cheetah population.</p><p>"People have an obsession with numbers. But I believe that it is more important to protect large landscape and habitats properly," Mills said.</p><p>He suggests that cheetahs enclosed within small reserves live in artificial conditions: "It's almost like glorified farming."</p><p>"In the long run we have to focus on consolidating formally protected areas," he added. "Africa's human population will double by 2050, so cheetah populations in unfenced areas will become unsustainable if they are eating people's livestock."</p>
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