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By Gudrun Heise
Just as scientists are scoring successes in coronavirus research, new problems are on their way. Fall is with us and winter is around the corner, so the season for colds and flu has begun — joining COVID-19.
The coronavirus is already new territory for science, and the effects of its combination with influenza are equally unknown. There is much speculation about what is to be expected and what will or could happen when these two dangerous infectious diseases come together. This is what is making it so difficult to prepare adequately for the cold time of year.
Coughing, sniffles and hoarseness in fall and winter are nothing new, and flu is also a regular feature of these seasons. But we can be vaccinated against it, and that is of advantage in diagnosing cases of coronavirus as well.
"If people who have been vaccinated against influenza still have flu symptoms, it is more likely that it is not influenza," says Gerárd Krause from the Helmholtz Centre for Infection Research in the northern German city of Braunschweig. "This, in turn, makes it easier to decide matters regarding home quarantine and getting a clear diagnosis."
A flu vaccination may thus be able to narrow down the diagnostic options when flu-like symptoms occur, but whether such a vaccination also has an influence on the behavior of the dangerous new virus is — like so much else — not clear. "It is conceivable that there is an indirect effect. But it is, I believe, a matter of speculation whether it has an immunological effect in the narrower sense," says Krause.
Every winter, doctors' waiting rooms are full of people who are coughing and sniffing but who mostly turn out to have only a severe respiratory infection. According to current knowledge, the virus that causes COVID-19, SARS-CoV-2, is also likely to be subject to seasonal fluctuations.
In winter, cold viruses, at least, flourish because cold and dry air offers ideal conditions for their spread. In addition, it becomes more difficult to air rooms regularly and intensively — an important further measure to counteract the coronavirus and contain to some extent the danger posed by aerosols.
According to the Robert Koch Institute, Germany's public health agency, between 5% and 20% of people in Germany become infected with flu viruses every year. These viruses are also dangerous and can be fatal. The flu vaccination must be adapted to the influenza viruses every year, because they mutate. But at least there is a vaccination.
Most experts agree that there is unlikely to be a vaccine against the coronavirus by the time the next wave of influenza comes around. And even if a vaccine were to be approved, many unknowns remain.
COVID-19 and Flu Simultaneously
For example, there is a lack of practical experience in dealing simultaneously with SARS-CoV-2 and influenza. It is possible to speculate that having influenza could facilitate the entry of the coronavirus into the human body. "The general weakening of the immune system during an influenza infection could increase the susceptibility of a patient to a SARS-CoV-2 infection," Krause says.
However, it is uncertain how dangerous this double infection could ultimately be and what can be done about it. Krause is of the opinion that we must arm ourselves against all three diseases — colds, flu and COVID-19. If we have a cold, bed rest, hot tea and cough medicine usually help. We can get vaccinated against flu. But how do we deal with COVID-19?
Probably people can only hope that if they get the illness, they will have a mild form with as few after-effects as possible. Here, it will certainly help to stick to suggested rules on hygiene to reduce or prevent our exposure to the virus. In an interview with DW, Bonn-based virology professor Hendrik Streeck made it clear that COVID-19 usually takes a more severe course when there is a high viral load at infection.
Hygiene, Hygiene, Hygiene
The same hygiene measures with which we are trying to get at least some kind of grip on COVID-19 also apply to influenza. The less we come into contact with viruses, the greater the chance that we will be spared an infection or that it will be mild.
These measures include general hygiene precautions such as frequent hand washing and the wearing of protective face masks. "The various hygienic measures against COVID-19 will also reduce the spread of influenza," says Krause. "Possibly, further connections of a more immunological nature will be discovered."
Let us hope that is the case, because the flu season hasn't even started.
Reposted with permission from Deutsche Welle.
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By Rebecca Niemiec and Kevin Crooks
Colorado voters will decide on Nov. 3 whether the state should reintroduce gray wolves (Canis lupus) after a nearly 80-year absence. Ballot Proposition 114 would require the state to develop and oversee a science-based plan to restore wolves, focused in Western Colorado and initiated by the end of 2023.
Back by Popular Demand?<img lazy-loadable="true" src="https://assets.rebelmouse.io/eyJhbGciOiJIUzI1NiIsInR5cCI6IkpXVCJ9.eyJpbWFnZSI6Imh0dHBzOi8vYXNzZXRzLnJibC5tcy8yNDUzOTQxNy9vcmlnaW4uanBnIiwiZXhwaXJlc19hdCI6MTYwNzI4NTkyMX0.BeRR61CH6a-TWwSw1p4kmng4x4tXRaSMKyTRHKIHmOw/img.jpg?width=980" id="1f7fe" class="rm-shortcode" data-rm-shortcode-id="339e3443dc63f3be06e24a82f0b37a03" data-rm-shortcode-name="rebelmouse-image" />
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Clashing Values<p>Proposition 114 has strong support in Colorado. <a href="https://extension.colostate.edu/topic-areas/people-predators/public-perspectives-on-wolves-and-wolf-reintroduction-8-004/" target="_blank">Statewide surveys </a> conducted by phone, by mail and online over the past two decades have found that 66% to 84% of respondents supported reintroducing wolves. This support is consistent across different regions of the state and diverse demographic groups.</p><p>In a <a href="https://doi.org/10.7717/peerj.9074" target="_blank">survey of Colorado residents</a> that we conducted in 2019, the prospect that wolves could contribute to a balanced ecosystem was the most commonly cited reason for supporting reintroduction. Other arguments included people's cultural and emotional connections to wolves, and <a href="https://extension.colostate.edu/topic-areas/people-predators/moral-arguments-related-to-wolf-restoration-and-management-8-011/" target="_blank" rel="noopener noreferrer">moral arguments</a> that restoring a species humans had eradicated was the right thing to do.</p><p>While overall public support is strong, over half of Colorado's 64 counties have passed <a href="https://www.drovers.com/article/wolf-reintroduction-ballot-colorado" target="_blank" rel="noopener noreferrer">resolutions against restoring wolves</a>. Many ranching and hunting associations are actively campaigning against the ballot measure.</p><p>In our 2019 study, we found that media coverage in the state focused more strongly on <a href="https://doi.org/10.7717/peerj.9074" target="_blank" rel="noopener noreferrer">perceived negative impacts</a> associated with wolf reintroduction than on beneficial effects. Surveys show that resident concerns include threats to <a href="https://extension.colostate.edu/topic-areas/people-predators/wolves-and-human-safety-8-003/" target="_blank" rel="noopener noreferrer">human safety and pets</a>; <a href="https://extension.colostate.edu/topic-areas/people-predators/wolves-and-livestock-8-010/" target="_blank" rel="noopener noreferrer">wolf attacks on livestock</a>; and the potential for wolves to <a href="https://extension.colostate.edu/topic-areas/people-predators/wolves-big-game-and-hunting-8-001/" target="_blank" rel="noopener noreferrer">reduce deer and elk populations</a>, threatening hunting opportunities.</p>
Who Decides?<p>This measure is the first giving voters in the U.S. an opportunity to weigh in on bringing back a native species. Addressing the issue through a ballot measure adds a unique twist to public and media discussions about wolves.</p><p>Supporters call it a democratic way to ensure that the <a href="https://www.cpr.org/2020/09/29/should-wolves-be-brought-back-to-colorado-a-rancher-and-a-biologist-have-their-say/" target="_blank">public's values are recognized</a>. They also argue that voters are deciding only whether wolves should be reintroduced, while allowing experts at the <a href="https://cpw.state.co.us/" target="_blank" rel="noopener noreferrer">state wildlife agency</a> to create a reintroduction plan <a href="https://www.steamboatpilot.com/news/election/howl-you-vote-wolf-advocates-opponents-ask-colorado/" target="_blank" rel="noopener noreferrer">based on the best available science</a>.</p>
<div id="4c11f" class="rm-shortcode" data-rm-shortcode-id="dec8674441e02372e50b796d848e4130"><blockquote class="twitter-tweet twitter-custom-tweet" data-twitter-tweet-id="1316474105315483649" data-partner="rebelmouse"><div style="margin:1em 0">According to a recent poll of 900 demographically representative likely voters, two-thirds supported “restoring wol… https://t.co/74LMG1PYtW</div> — High Country News (@High Country News)<a href="https://twitter.com/highcountrynews/statuses/1316474105315483649">1602706860.0</a></blockquote></div>
Finding Consensus<p>Studies suggest that ballot initiatives like 114 will <a href="https://doi.org/10.1016/j.biocon.2017.07.032" target="_blank">become more common</a> as public values toward wildlife change and more diverse groups seek to influence wildlife management. For us, the key question is how to recognize and incorporate these differing values as agencies make decisions.</p><p>Research drawing on insights from <a href="https://extension.colostate.edu/topic-areas/people-predators/dialogue-and-social-conflict-about-wolves-8-009/" target="_blank">psychology, political science and sociology</a> suggests that it is critical to run<a href="https://drive.google.com/file/d/1QppmBszEF6zsNnhBJ7Q2-pSWRR-Zx_ln/view" target="_blank" rel="noopener noreferrer"> truly participatory processes</a> that engage government agencies and people who have a stake in the issue in shared decision-making. Fostering dialogue between groups that value wildlife differently can build empathy and mutual understanding and <a href="https://doi.org/10.1016/j.biocon.2014.07.015" target="_blank" rel="noopener noreferrer">foster compromise</a>. Broadening the conversation in this way is essential for coexisting with carnivores with minimal impacts on predators and people.</p>
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By Brian Bienkowski
Fish exposed to endocrine-disrupting compounds pass on health problems to future generations, including deformities, reduced survival, and reproductive problems, according to a new study.
Low Levels Lead to Generational Impacts<p>Researchers exposed inland silverside fish to bifenthrin, levonorgestrel, ethinylestradiol, and trenbolone to levels currently found in waterways.</p><p>"Our concentrations were actually on the low end" of what is found in the wild, DeCourten said, adding that it was low amounts of chemicals in parts per trillion.</p><p>Bifenthrin is a pesticide; levonorgestrel and ethinylestradiol are synthetic hormones used in birth controls; and trenbolone is a synthetic steroid often given to cattle to bulk them up.</p><p>Such endocrine-disruptors have already been linked to a variety of health problems in directly exposed fish including altered growth, reduced survival, lowered egg production, skewed sex ratios, and negative impacts to immune systems. But what remains less clear is how the exposure may impact future generations.</p><p>For their study, DeCourten and colleagues started the exposure when the fish were embryos and continued it for 21 days.</p><p>They then tracked effects on the exposed fish, and the next two generations.</p>
Inherited Problems<p>DeCourten said the altered DNA methylation is one of the plausible ways that future generations would experience health impacts from previous generations' exposure. Hormone-disrupting compounds have been shown to impact DNA methylation, which is an important marker of how an organism will develop.</p><p>"Methyl groups are added to specific sites on the genome, [the exposure] is not changing the genome itself, but rather how the genome is expressed," she said. "And that can be inherited throughout generations."</p><p>In addition, Brander said there are essentially different "tags" that exist on DNA molecules, which tell genes how to turn on and off. She said the exposure to different compounds may be "influencing which methyl tags get taken on or off as you proceed through generations."</p><p>The researchers said the study should prompt future toxics testing to consider impacts on future generations.</p><p>"The results … throw a wrench in the current approach to regulating chemicals, where it's often short-term testing looking at simple things like growth, survival, and maybe gene expression," Brander said.</p><p>"These findings are telling us we really at least need to consider" the next two generations, she added.</p>
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