Moderna, Pfizer Release Study Designs as Vaccine Distrust Grows Among Americans
The secretive blueprints for two of the leading vaccine candidates for the coronavirus were released Thursday. Pfizer and Moderna became the first two companies among the nine leading vaccine candidates to share their study designs, hoping that the disclosures will create trust and clarity for the public, as The New York Times reported.
The details that the two companies shared are usually kept secret until after a study is complete, yet the companies decided to publish the size of their trials, the selection criteria for patients, and the adverse reactions that would cause the trials to stop prematurely. The Moderna trial will include 30,000 participants, while the Pfizer trial will have 44,000 participants, according to The New York Times.
The information released shows that the two companies and their executives still do not know if the vaccines are safe and effective. Furthermore, the disclosure shows that the ambitious time frame that President Trump touts to have a vaccine available in a few weeks is all but impossible, according to The Washington Post.
Trump's frequent comments about the availability of a vaccine to the general population by election day contradict the word of scientists, health officials and the companies manufacturing and testing the vaccine candidates. That mixed-messaging has sown confusion with the public and created the appearance that a vaccine candidate will be rushed to market prior to proving its safety and efficacy, according to The Washington Post.
"We need trust as much as we need efficacy," said Andrew Pavia, an infectious-diseases specialist at the University of Utah School of Medicine, to The Washington Post. "We can't afford to do anything that reduces the trust. It's not just the trust of the public. Experts in the field have to see enough of the data to feel comfortable to recommend it."
New poll number show that trust is eroding. Data released Thursday by the Pew Research Center show that the number of Americans who are willing to get a vaccine for the coronavirus has dropped precipitously since the beginning of the pandemic.
According to the new poll, about 51 percent of the population is likely to get the vaccine, while 49 percent said they are unwilling or unlikely to get it. Only 21 percent said they would definitely get the vaccine.
The percentage of people who were likely to get the vaccine is down from 72 percent in May, marking a 21 percent drop over the summer. The thorniest issue for study participants was their growing concern that a vaccine was being developed too fast and it would be widely distributed before it was proven to be safe and effective.
"Over the past month alone — a period in which President Donald Trump has repeatedly promised a vaccine will be delivered by the end of 2020 and possibly before the Nov. 3 election — the share of adults who say they would get vaccinated has fallen 8 points after public opinion on the matter generally remained steady over the summer," the researchers wrote, as The Hill reported.
That growing unease about a vaccine is what prompted the nine companies with the leading vaccine candidates to take the unusual step of banding together to pledge that a vaccine would not be released prematurely, according to The Hill. For a vaccine to be effective, confidence has to grow so enough people will receive the vaccine to raise immunity levels high enough to stop transmission of the virus.
As for a realistic timeframe, Thursday's disclosures by Moderna and Pfizer showed that there would not be a vaccine from either company by election day. Moderna's estimated timetable showed it would not likely know if its candidate works until 2021. Pfizer did not release an estimated timetable in its disclosure, according to The New York Times.
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Trump Calls Fauci 'a Disaster,' Tries to Blame Science and Medical Experts for Failed Coronavirus Response
President Trump attacked the nation's top infectious disease specialist in a call with campaign staffers that several reporters were allowed to listen to on Monday. In the call, Trump said that Dr. Anthony S. Fauci was "a disaster." He added that despite the evidence that coronavirus cases are once again rising across the country, the public was tired of hearing so much news about the virus, especially from "these idiots" in the government and scientific community, as The Washington Post reported.
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EcoWatch Daily Newsletter
By Rebecca Niemiec and Kevin Crooks
Colorado voters will decide on Nov. 3 whether the state should reintroduce gray wolves (Canis lupus) after a nearly 80-year absence. Ballot Proposition 114 would require the state to develop and oversee a science-based plan to restore wolves, focused in Western Colorado and initiated by the end of 2023.
Back by Popular Demand?<img lazy-loadable="true" src="https://assets.rebelmouse.io/eyJhbGciOiJIUzI1NiIsInR5cCI6IkpXVCJ9.eyJpbWFnZSI6Imh0dHBzOi8vYXNzZXRzLnJibC5tcy8yNDUzOTQxNy9vcmlnaW4uanBnIiwiZXhwaXJlc19hdCI6MTYwNzI4NTkyMX0.BeRR61CH6a-TWwSw1p4kmng4x4tXRaSMKyTRHKIHmOw/img.jpg?width=980" id="1f7fe" class="rm-shortcode" data-rm-shortcode-id="339e3443dc63f3be06e24a82f0b37a03" data-rm-shortcode-name="rebelmouse-image" />
<span style="display:block;position:relative;padding-top:56.25%;" class="rm-shortcode" data-rm-shortcode-id="9aec767b3325e364a8605524504f95ab"><iframe lazy-loadable="true" src="https://www.youtube.com/embed/wTx_jqpqqfU?rel=0" width="100%" height="auto" frameborder="0" scrolling="no" style="position:absolute;top:0;left:0;width:100%;height:100%;"></iframe></span>
Clashing Values<p>Proposition 114 has strong support in Colorado. <a href="https://extension.colostate.edu/topic-areas/people-predators/public-perspectives-on-wolves-and-wolf-reintroduction-8-004/" target="_blank">Statewide surveys </a> conducted by phone, by mail and online over the past two decades have found that 66% to 84% of respondents supported reintroducing wolves. This support is consistent across different regions of the state and diverse demographic groups.</p><p>In a <a href="https://doi.org/10.7717/peerj.9074" target="_blank">survey of Colorado residents</a> that we conducted in 2019, the prospect that wolves could contribute to a balanced ecosystem was the most commonly cited reason for supporting reintroduction. Other arguments included people's cultural and emotional connections to wolves, and <a href="https://extension.colostate.edu/topic-areas/people-predators/moral-arguments-related-to-wolf-restoration-and-management-8-011/" target="_blank" rel="noopener noreferrer">moral arguments</a> that restoring a species humans had eradicated was the right thing to do.</p><p>While overall public support is strong, over half of Colorado's 64 counties have passed <a href="https://www.drovers.com/article/wolf-reintroduction-ballot-colorado" target="_blank" rel="noopener noreferrer">resolutions against restoring wolves</a>. Many ranching and hunting associations are actively campaigning against the ballot measure.</p><p>In our 2019 study, we found that media coverage in the state focused more strongly on <a href="https://doi.org/10.7717/peerj.9074" target="_blank" rel="noopener noreferrer">perceived negative impacts</a> associated with wolf reintroduction than on beneficial effects. Surveys show that resident concerns include threats to <a href="https://extension.colostate.edu/topic-areas/people-predators/wolves-and-human-safety-8-003/" target="_blank" rel="noopener noreferrer">human safety and pets</a>; <a href="https://extension.colostate.edu/topic-areas/people-predators/wolves-and-livestock-8-010/" target="_blank" rel="noopener noreferrer">wolf attacks on livestock</a>; and the potential for wolves to <a href="https://extension.colostate.edu/topic-areas/people-predators/wolves-big-game-and-hunting-8-001/" target="_blank" rel="noopener noreferrer">reduce deer and elk populations</a>, threatening hunting opportunities.</p>
Who Decides?<p>This measure is the first giving voters in the U.S. an opportunity to weigh in on bringing back a native species. Addressing the issue through a ballot measure adds a unique twist to public and media discussions about wolves.</p><p>Supporters call it a democratic way to ensure that the <a href="https://www.cpr.org/2020/09/29/should-wolves-be-brought-back-to-colorado-a-rancher-and-a-biologist-have-their-say/" target="_blank">public's values are recognized</a>. They also argue that voters are deciding only whether wolves should be reintroduced, while allowing experts at the <a href="https://cpw.state.co.us/" target="_blank" rel="noopener noreferrer">state wildlife agency</a> to create a reintroduction plan <a href="https://www.steamboatpilot.com/news/election/howl-you-vote-wolf-advocates-opponents-ask-colorado/" target="_blank" rel="noopener noreferrer">based on the best available science</a>.</p>
<div id="4c11f" class="rm-shortcode" data-rm-shortcode-id="dec8674441e02372e50b796d848e4130"><blockquote class="twitter-tweet twitter-custom-tweet" data-twitter-tweet-id="1316474105315483649" data-partner="rebelmouse"><div style="margin:1em 0">According to a recent poll of 900 demographically representative likely voters, two-thirds supported “restoring wol… https://t.co/74LMG1PYtW</div> — High Country News (@High Country News)<a href="https://twitter.com/highcountrynews/statuses/1316474105315483649">1602706860.0</a></blockquote></div>
Finding Consensus<p>Studies suggest that ballot initiatives like 114 will <a href="https://doi.org/10.1016/j.biocon.2017.07.032" target="_blank">become more common</a> as public values toward wildlife change and more diverse groups seek to influence wildlife management. For us, the key question is how to recognize and incorporate these differing values as agencies make decisions.</p><p>Research drawing on insights from <a href="https://extension.colostate.edu/topic-areas/people-predators/dialogue-and-social-conflict-about-wolves-8-009/" target="_blank">psychology, political science and sociology</a> suggests that it is critical to run<a href="https://drive.google.com/file/d/1QppmBszEF6zsNnhBJ7Q2-pSWRR-Zx_ln/view" target="_blank" rel="noopener noreferrer"> truly participatory processes</a> that engage government agencies and people who have a stake in the issue in shared decision-making. Fostering dialogue between groups that value wildlife differently can build empathy and mutual understanding and <a href="https://doi.org/10.1016/j.biocon.2014.07.015" target="_blank" rel="noopener noreferrer">foster compromise</a>. Broadening the conversation in this way is essential for coexisting with carnivores with minimal impacts on predators and people.</p>
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By Brian Bienkowski
Fish exposed to endocrine-disrupting compounds pass on health problems to future generations, including deformities, reduced survival, and reproductive problems, according to a new study.
Low Levels Lead to Generational Impacts<p>Researchers exposed inland silverside fish to bifenthrin, levonorgestrel, ethinylestradiol, and trenbolone to levels currently found in waterways.</p><p>"Our concentrations were actually on the low end" of what is found in the wild, DeCourten said, adding that it was low amounts of chemicals in parts per trillion.</p><p>Bifenthrin is a pesticide; levonorgestrel and ethinylestradiol are synthetic hormones used in birth controls; and trenbolone is a synthetic steroid often given to cattle to bulk them up.</p><p>Such endocrine-disruptors have already been linked to a variety of health problems in directly exposed fish including altered growth, reduced survival, lowered egg production, skewed sex ratios, and negative impacts to immune systems. But what remains less clear is how the exposure may impact future generations.</p><p>For their study, DeCourten and colleagues started the exposure when the fish were embryos and continued it for 21 days.</p><p>They then tracked effects on the exposed fish, and the next two generations.</p>
Inherited Problems<p>DeCourten said the altered DNA methylation is one of the plausible ways that future generations would experience health impacts from previous generations' exposure. Hormone-disrupting compounds have been shown to impact DNA methylation, which is an important marker of how an organism will develop.</p><p>"Methyl groups are added to specific sites on the genome, [the exposure] is not changing the genome itself, but rather how the genome is expressed," she said. "And that can be inherited throughout generations."</p><p>In addition, Brander said there are essentially different "tags" that exist on DNA molecules, which tell genes how to turn on and off. She said the exposure to different compounds may be "influencing which methyl tags get taken on or off as you proceed through generations."</p><p>The researchers said the study should prompt future toxics testing to consider impacts on future generations.</p><p>"The results … throw a wrench in the current approach to regulating chemicals, where it's often short-term testing looking at simple things like growth, survival, and maybe gene expression," Brander said.</p><p>"These findings are telling us we really at least need to consider" the next two generations, she added.</p>
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