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9 Best CBD Oil Brands for Anxiety & Depression Reviewed 2021

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CBD Oil Collage

CBD Oil for Anxiety

In the past several years, CBD has become a popular and natural way for people to help manage their anxiety. What is the best CBD for anxiety? And how does CBD help with anxiety? In this article, we highlight our favorite brands of CBD for anxiety and provide important background information on how to use CBD oils to help manage anxiety and depression.


CBD stands for cannabidiol, and it is one of the active ingredients found in cannabis. Though CBD is a critical component in medical marijuana, most commercially available CBD products are derived from the hemp plant. These products are said to offer a range of personal health benefits, and one of the most significant of those benefits is relief from anxiety.

A Harvard report notes that CBD is commonly used as a way to manage anxiety symptoms, and that those who struggle with various mental health concerns may use CBD to help them combat sleeplessness.

But what does the science really say about using CBD oil for anxiety and depression? And for those who wish to use CBD products to help with anxiety, what are the best CBD for anxiety brands out there?

Does CBD Help for Anxiety?

Studies show that, while CBD doesn't necessarily alter a person's baseline anxiety level, it may be useful for reducing experiential anxiety. Indeed, research points to CBD as a potentially effective way to address the symptoms of seasonal affective disorder (SAD), generalized anxiety disorder (GAD), and post traumatic stress disorder (PTSD). Additional research indicates that CBD "has a promising role as alternative therapy in the management of anxiety disorders," though more clinical testing is needed to verify safe dosage levels.

Based on the available evidence, CBD may potentially help manage the symptoms of anxiety, though it is not a cure. Be sure to consult with your primary care physician or mental health care provider before taking CBD for anxiety and depression if you have any questions or concerns.

Best CBD Oil for Anxiety: Top Brands for 2021

Each product featured here has been independently selected by the writer. You can learn more about our review methodology here. If you make a purchase using the links included, we may earn commission.

How We Chose the Best CBD for Anxiety & Depression

When creating our list of the best CBD oils for anxiety and depression, we compared brands and products ib six specific categories.

  • Type of CBD — Does the brand use full spectrum, broad spectrum, or CBD isolate?
  • Strength — How many milligrams of CBD does the oil contain per recommended dose?
  • Source — Where does the get the hemp used in their hemp extract? Is it grown in the U.S.?
  • Flavor — Do they offer multiple flavors, and if so, do they use natural flavoring instead of artificial flavors?
  • Transparency — Is the product tested by an independent third-party lab and do they make the results easy to access?
  • Customer Experience — What are customers saying about the product and if it has helped them manage stress and anxiety?

Learn more about each of the CBD oils on our list below.

9 Best CBD Oils for Anxiety & Depression

Best Overall: CBDistillery

CBDistillery Relief + Relax CBD Oil

thecbdistillery.com

CBDistillery is known for high-quality, pure CBD products, and their full spectrum oil is a great choice to help you relax. All of their products are third-party lab tested and confirmed to be safe and effective. We like their Relief + Relax CBD oil because it is a full spectrum oil that provides plenty of additional active cannabinoids and plant compounds like CBG, CBC, and terpenes to give you the full benefits of the entourage effect.

  • CBD: Full Spectrum
  • Strength: 33 mg CBD per serving (1000 mg per bottle)
  • Hemp source: Colorado

Why buy: We love this strong full spectrum CBD oil for anxiety because it is sourced from non-GMO, U.S. Hemp Authority Certified hemp grown in Colorado. Taking CBD Relief + Relax in the morning may be a great way to support a sense of calm throughout the day.

$60

Strongest Full Spectrum: Spruce

Spruce Full Specrum CBD Oil

takespruce.com

Spruce CBD Oil

Spruce CBD oil checks all of the right boxes: it's all-natural, made from USA-grown hemp, and is backed by rigorous third-party lab testing. You can get this lab-grade CBD oil tincture in a range of potencies, ranging from 750 mg to 2,400 mg per bottle. We like that Spruce CBD oil is all-natural, organic, vegan, gluten-free, and contains no artificial flavors, preservatives, or sweeteners. Note that Spruce products may be too strong for entry-level customers.

  • CBD: Full Spectrum
  • Strength: 25 mg to 80 mg of CBD per serving
  • Hemp source: Kentucky and North Carolina

Why buy: We love that Spruce offers some of the strongest full spectrum CBD products, including their extra strength formula with 80 mg of CBD per serving. We recommend it for experienced CBD users looking for powerful relief from feelings of anxiety and stress.

$89

Best Broad Spectrum: Charlotte's Web

Charlotte's Web THC Free CBD Oil

charlottesweb.com

Charlotte's Web THC Free CBD Oil offers many of the same benefits found in their original full spectrum products, but without the THC. It is a great option for those who want natural relief from anxiety or stress but are concerned about adding THC to their system. The full complement of phytocannabinoids, terpenes, flavonoids, and fatty acids in this oil may help you reduce everyday stressors.

  • CBD: Broad Spectrum
  • Strength: 25 mg CBD per serving (750 mg per bottle)
  • Hemp Source: Colorado
Why buy: We love this broad spectrum oil from Charlotte's Web because it offers more benefits than a CBD isolate but without the THC of a full spectrum product. This may be a good choice to help ease stress for anyone sensitive to THC or who wants to avoid it altogether.
$60

Best Full Spectrum: NuLeaf Naturals

NuLeaf Naturals CBD Oil

nuleafnaturals.com

NuLeaf Naturals CBD oil is about as natural as a CBD tincture can get. It's made from organic hemp, it's additive- and pesticide-free, and it's carefully lab-tested by independent third-party labs. This Colorado-grown, full spectrum CBD offers the full benefits of hemp extract in a natural, organic product. It may be taken daily to help you manage stress and feelings of anxiety by promoting a sense of calm and wellness.

  • CBD: Full Spectrum
  • Strength: 30 mg of CBD per serving (1800 mg per bottle)
  • Hemp source: Colorado

Why buy: We love this strong full spectrum CBD oil because of its simplicity. It contains organic full spectrum hemp extract and organic virgin hemp seed oil. NuLeaf Naturals also provides a consistent concentration of CBD across all bottle sizes to make dosing easier.

$79

Best THC-Free: Medterra

Medterra CBD Oil

medterra.com

Medterra offers a wide range of CBD products, including topicals, pet products, and more. We like their CBD oil because it is THC-free and is made with organically-grown, Co2-extracted hemp. Their oils only contain CBD and MCT oil (basically a saturated fatty acid), and they meet rigorous third-party testing standards. You can choose between 500 mg, 1000 mg, and 3000 mg options to find the right amount for your needs.

  • CBD: Broad Spectrum
  • Strength: 16 mg CBD per serving (500 mg per bottle)
  • Hemp source: Kentucky

Why buy: This CBD oil is U.S. Hemp Authority Certified and uses organic, Kentucky-grown hemp to provide natural support for anxiety and stress. We recommend Medterra because of their commitment to rigorous quality and safety standards, and because all of their products are THC-free.

$35

Best Organic: Cornbread Hemp

Cornbread Hemp Distilled CBD Oil

cornbreadhemp.com

To make their Distilled CBD Oil, Cornbread Hemp extracts CBD only from hemp flowers. This distillation allows the oil to maintain a full spectrum of cannabinoids, with a CBD-to-THC ratio of 27:1. Lower in THC than their Whole Flower oil, this product is better for finding comfort during the day while staying focused and alert. Cornbread Hemp CBD is USDA organic and offers a cleaner tasting oil than some whole plant extracts.

  • CBD: Full Spectrum
  • Strength: 50mg per 1mL serving
  • Hemp source: Kentucky

Why buy: We love this Cornbread Hemp Distilled CBD Oil because it uses whole flower CBD extract for a cleaner product and milder taste. It may be a great way to help ease anxiety during the day without drowsiness or loss of focus. Plus, it's USDA-certified organic with third-party, ISO certified lab tests on every batch.

$60

Best Doctor-Formulated: Wonderfeel

Wonderfeel Daytime CBD Extra Strength

wonderfeel.co

Wonderfeel Daytime CBD Extra Strength tincture offers a super-concentrated dose of doctor-formulated CBD to help you enjoy a sense of calm throughout the day. Made with organically-grown broad spectrum CBD, their formula also contains a rich terpene complex for added benefits, and no THC. This CBD oil may help enhance your focus while easing stress and promoting calm during the day.

  • CBD: Broad Spectrum
  • Strength: 45 mg of CBD per 1 mL (1350 mg per bottle)
  • Source: USA

Why buy: We like this Wonderfeel Daytime CBD because it's designed to keep you calm and relaxed while also helping you focus. We also like that they use non-GMO ingredients and organic hemp grown without pesticides to offer a potent and safe product.

$75

Best Selection: cbdMD

cbdMD Premium CBD Oils

cbdmd.com

cbdMD oils are made from USA-grown hemp and come in a variety of flavors and concentrations. These broad spectrum oils allow you to get a range of cannabinoids, terpenes, and other valuable plant compounds with no THC. For people who want to take CBD to help manage stress at work, cbdMD may provide relief without the risk of a failed drug test. cbdMD makes it easy to find the right strength and flavor for you.

  • CBD: Broad Spectrum
  • Strength: 10 mg to 250 mg CBD per serving (300 mg to 7500 mg per bottle)
  • Hemp source: USA

Why buy: We love that cbdMD offers such a wide selection of strengths and flavors. These CBD oils may be a great way to naturally promote a greater sense of calm and relaxation to help you manage stress and anxiety.

$30

Best Value: Naternal

Naternal Original Full Spectrum CBD Oil

naternal.com

Naternal CBD is made from North Carolina grown hemp and offers a light, natural flavor in a nearly-clear oil. You can get this lab-grade full spectrum tincture in 20 mg , 40 mg, or 80 mg per serving concentrations. Once you find the right dose of Naternal, the strong effects can help you fall asleep easily or allow you to relax with a strong body relaxation. It's a great product for natural anxiety support at an affordable price.

  • CBD: Full Spectrum
  • Strength: 20 mg, 40 mg, or 80 mg CBD per 1mL serving
  • Hemp source: North Carolina

Why buy: We love Naternal Full Spectrum CBD because it comes with simple dosing instruction on every package and at a very affordable price. This oil may help you relax and destress at the end of the day or before bedtime.

$40

Using CBD to Help With Anxiety & Depression: What the Research Says

As cited above, initial research has found that CBD has the potential to help manage the symptoms of anxiety in a variety of cases.

There is also clinical evidence to suggest that CBD can be a tool for managing panic attacks. Panic disorder (PD) impacts about five percent of the total global population, making the anxiolytic effects of CBD products potentially impactful on a widespread level.

There is even clinical evidence that CBD may help minimize the symptoms of obsessive compulsive disorder (OCD), a nervous condition that can be debilitating. Currently, OCD is treated primarily through cognitive behavioral therapy and antidepressants, but the recovery rate is exceedingly low. The prospect of CBD as an alternative intervention is potentially game-changing.

But how exactly does CBD impact those with anxiety conditions? The short answer is that products from the cannabis plant tend to have a strong, reactive effect with the endocannabinoid system, a molecular system that regulates many core functions of the body, including emotions. Cannabinoids can bind to receptors in the endocannabinoid system and modify the way they function, yielding a range of possible health benefits.

In fact, one study notes that "modulating the activity of the endocannabinoid system turned out to hold therapeutic promise in a wide range of disparate diseases and pathological conditions, ranging from mood and anxiety disorders, movement disorders such as Parkinson's and Huntington's disease, neuropathic pain, multiple sclerosis and spinal cord injury, to cancer, atherosclerosis, myocardial infarction, stroke, hypertension, glaucoma, obesity/metabolic syndrome, and osteoporosis, to name just a few."

While CBD may potentially help to manage stress and anxiety, it is not intended as a cure for anxiety or depression.

Related: Best CBD Oils for Pain Management 2021

How to Choose CBD Oil for You

When you're looking for the best CBD for depression and anxiety, it's important to choose a product that is safe, effective, and natural. Here are some important things to keep in mind when shopping for CBD.

What to Look For

Always look for the following pieces of information when comparing CBD oils for anxiety: type of CBD, hemp source, strength, and lab testing. Below are more details on what each of these mean and why they matter.

Type of CBD

There are actually three different types of CBD extract, including full spectrum, broad spectrum, and CBD isolate. We typically recommend full spectrum products as the most effective, as they allow you to benefit from the full entourage effect of the hemp extract. However, if you undergo drug testing for work or are sensitive to THC, broad spectrum products offer many of the same benefits without the THC. This can also be important for those who find that THC negatively impacts their anxiety.

Hemp Source

The quality of the CBD is directly related to the source of the hemp used in a product. Always look for brands that use hemp grown in the U.S.A. We also recommend brands that use either USDA organic hemp or hemp grown using organic farming practices. This ensures that the plants do not contain any pesticides and or artificial fertilizers.

Strength

It's important to know the concentration of CBD in a product so that you can take the appropriate dosage level. For those new to CBD, it's generally recommended to start with a lower dose, 10 mg or less, and slowly increase the amount as you are comfortable to find the right level of relief. Extra strength products, with 30 mg or more per serving, are recommended for those who know how CBD will affect them. You can read more about the strongest CBD oils here.

Lab Testing

Only purchase CBD oils for anxiety that undergo independent third-party lab testing for quality and safety. This is critical to ensure that the product contains the correct levels of CBD and cannabinoids, and that it is free from toxins, heavy metals, or other harmful substances. The brands we recommend all make their lab test results available through QR codes on the product label or on their site.

How to Read Labels

When you check the label of any CBD product, look for information on the four key factors listed above. Labels should clearly state the type of CBD and if it was made with U.S. grown hemp. To evaluate the strength of the product, look for both the amount of CBD per bottle, usually in milligrams per 30 mL, as well as the amount of CBD per serving, usually in milligrams per 1 mL dropper.

Quality products should also include lab-testing certification and a way for you to verify the results for yourself. You can also look for industry certifications and seals from the USDA, Leaping Bunny, the GMO Project, and the U.S. Hemp Authority. Finally, take time to check the list of ingredients to make sure that you are not allergic to any of them. Most CBD oils use a carrier oil like hemp seed oil, olive oil, or MCT coconut oil.

How to Use

For most CBD oils, take a dose once or twice per day, depending on the amount. Some oils work better for daytime use and can be taken in the morning, while others are better suited for nighttime use to help you fall asleep. Again, if you are new to CBD, start with a low amount and slowly increase it to find the correct level to provide relief.

The amount of CBD needed may vary from person to person based on their level of anxiety and other health concerns. One thing that holds true across the board is that using CBD consistently is best for improving stress levels, as the compound builds up within the body, amplifying its effect. In other words, CBD may help you manage anxiety symptoms, but don't expect it to take effect immediately.

Safety & Side Effects

According to the Mayo Clinic, CBD is generally well-tolerated. There are, however, some mild side effects that can occur. These often result from taking too much CBD, and can include:

  • Dry mouth
  • Diarrhea
  • Reduced appetite
  • Drowsiness
  • Fatigue
Additionally, CBD can potentially interact with certain prescription medications, like blood thinners and certain forms of statins. Always check with your doctor if you plan to start using CBD alongside any prescription medications. No CBD product has been approved by the FDA to treat anxiety or depression, so be sure to do your own research on any product you choose to purchase.

Alternative Options

While CBD may be a great option to help supplement your anxiety management, it is not meant to cure or treat anxiety. If you are suffering from severe anxiety and depression, the best thing to do is speak with your primary care physician or a mental health professional. They may recommend things like cognitive behavioral therapy, journaling, exercise, yoga, or prescription medications to help.

If approved by your doctor, CBD for depression and anxiety may work with these other approaches to help you find relief and better manage stress.

Josh Hurst is a journalist, critic, copywriter, and essayist. He lives in Knoxville, TN, with his wife and three sons. As a writer and independent reviewer of CBD products, Josh covers the relationship between cannabis-based products and the human body. His writing has appeared in Health, Shape, and Remedy Review.

Medically Reviewed By:

Alan Carter
PharmD Scientific Advisor, Medical Reviewer, and Clinical Pharmacist
Adjunct Faculty, UMKC School of Pharmacy

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